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In search of the biological significance of modular structures in protein networks
05-30-2007 · EurekAlert!Refuting previous studies, the authors show by computer simulation that modular structures can arise during network growth via a simple model of gene duplication, without a natural selection preference for modularity.
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Keywords: search, biological, significance, modular, structures, protein, networks, structure, network
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- Mind the gap
11-22-2006 · EurekAlert!
Researchers have found a gap between water and a water-repelling surface that can give new insight into the way water and oil separate. By using high-energy X-rays at the ESRF, an international team defined the size and characteristics of this gap. The knowledge of the structure of a hydrophobic interface is important because they are crucial in biological systems, and can give insight in protein folding and stability.
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- First high-res 3D structures of mammalian HSP90 protein solved
10-12-2007 · EurekAlert!
Dr. Dan Gewirth, Hauptman-Woodward senior research scientist, has just solved the structure of the first mammalian GRP94 protein implicated in immune diseases such as sepsis, AIDS and certain cancers. His work is being published today in a cover article in Molecular Cell. Gewirth's study confirms his hypothesis that this protein -- GRP94 -- is from the same family as the better known HSP90 proteins.
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- Zinc Transporter Protein Structure Deciphered
08-23-2007 · Brookhaven National Laboratory
Scientists at Brookhaven have deciphered the atomic-level structure of a cell-membrane protein that regulates the movement of zinc ions into and out of cells. Details of the structure may help scientists better understand the crucial role zinc plays in many biological process, from nerve cell communication to insulin regulation.
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- Crystal structure enables tailoring of pharmaceuticals against asthma
07-16-2007 · EurekAlert!
Researchers at Karolinska Institutet in Sweden have managed to elucidate the crystal structure of a human membrane protein -- LTC4 synthase -- which has a major influence on the development of asthma. LTC4 synthase is extremely difficult to analyze, and previously only low resolution information has been available on two membrane protein structures from human. The scientists now believe that their work will enable the development of new and better therapeutics against inflammations in the pulmonary tract.
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- Self-assembling nano-ice discovered at UNL -- Structure resembles DNA
12-11-2006 · EurekAlert!
UNL chemist Xiao Cheng Zeng and his team discovered double helixes of ice molecules that resemble the structure of DNA and self-assemble under high pressure inside carbon nanotubes. This discovery could have major implications for scientists in other fields who study the protein structures that cause diseases such as Alzheimer's and bovine spongiform ecephalitis. It could also help guide those searching for ways to target or direct self-assembly in nanomaterials.
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- Connection between startled response and schizophrenia
11-12-2007 · EurekAlert!
The search for responsible genes for prepulse inhibition, a measure deemed to be a biological trait in schizophrenia, has exposed a gene encoding essential fatty acid-binding protein.
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- Protein's strength lies in h-bond cooperation
02-14-2008 · EurekAlert!
Researchers in Civil and Environmental Engineering at MIT reveal that the strength of a biological material like spider silk lies in the geometric configuration of structural proteins, and the small clusters of weak hydrogen bonds that work cooperatively to resist force and dissipate energy. This structure makes protein-based materials as strong as steel, even though the hydrogen bonds that hold them together are 100 to 1,000 times weaker than the metallic bonds in steel.
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- Unique partnership produces life-critical 3D structures
03-28-2007 · EurekAlert!
Most diseases are caused by malfunctions in the body’s complex protein machinery. The next generation of drugs will be designed on the basis of 3D protein models that scientists are creating. The Structural Genomics Consortium laboratory at Karolinska Institutet in Sweden has now made available the structure of PARP3, the four hundredth structure in this unique project to chart the body’s proteins.
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- Casting the molecular net
06-14-2007 · EurekAlert!
Scientists at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital, European Molecular Biology Laboratory, and Massachusetts Institute of Technology have created a new computational method called NetworKIN. This method uses biological networks to better identify relationships between molecules. In a cover story featured in the June 29, 2007, edition of the journal Cell, the scientists report insights into the regulation of protein networks that will ultimately help to target human disease.
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- Protein structures for the entire yeast proteome
03-19-2007 · EurekAlert!
Protein three-dimensional structures were predicted for all Saccharomyces cerevisiae domains that were found to have no sequence similarity to any proteins of known structure.
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