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Extensively drug-resistant tuberculosis is emerging threat

Strains of tuberculosis (TB) that are resistant to both first-line and second-line drugs could threaten the success of not only tuberculosis programs, but also HIV treatment programs worldwide, according to an article published online this week in the Lancet.

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Keywords: extensively, drug-resistant, tuberculosis, emerging, threat, drug, resistant, tuberculosi

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1. Scientists decode genome of tuberculosis microbe
   11-26-2007 · Massachusetts Institute of Technology (MIT)
   An international collaboration led by researchers in the US and South Africa announced Nov. 20 the first genome sequence of an extensively drug resistant (XDR) strain of the bacterium Mycobacterium tuberculosis.
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2. NIAID releases MDR/XDR Tuberculosis research agenda
   06-06-2007 · EurekAlert!
   NIAID today released its NIAID Research Agenda for Multidrug-Resistant (MDR) and Extensively Drug-Resistant (XDR) Tuberculosis (TB). While focusing on MDR/XDR TB, many of the research priorities identified in this document also relate to drug-sensitive tuberculosis. The research priorities identified in the agenda build on a foundation of ongoing NIAID-supported TB research, which currently comprises more than 300 research projects worldwide.
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3. Simple strategy could prevent half of deadly tuberculosis infections
   12-18-2007 · EurekAlert!
   By using a combination of inexpensive infection control measures, hospitals around the world could prevent half the new cases of extensively drug resistant tuberculosis, according to a new study in the Lancet by researchers at Yale School of Medicine.
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4. Scientists decode genomes of diverse TB isolates
   11-20-2007 · EurekAlert!
   Collaboration led by US and South Africa researchers announced the first genome sequence of an extensively drug-resistant strain of Mycobacterium tuberculosis linked to more than 50 deaths in a recent TB outbreak in KwaZulu-Natal, South Africa. Initial comparisons of the genome sequences reveal that drug-resistant and drug-sensitive microbes differ at only a few dozen locations along the 4-million-letter DNA code.
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5. HIV/AIDS linked to extensively drug resistant TB
   11-10-2006 · EurekAlert!
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6. XDR TB in South Africa traced to lack of drug susceptibility testing
   10-22-2007 · EurekAlert!
   In South Africa, the 2001 implementation of the World Health Organization's antituberculosis program may have inadvertently helped to create a new strain of extensively drug-resistant tuberculosis. In a new study published in the Dec. 1 issue of Clinical Infectious Diseases, currently available online, researchers tracked the developing drug resistance of one particular strain of Mycobacterium tuberculosis over 12 years.
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7. Infectious diseases experts applaud bill against 'bad bugs'
   10-31-2007 · EurekAlert!
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8. Infectious diseases experts applaud bill against 'bad bugs'
   09-28-2007 · EurekAlert!
   With extensively drug-resistant tuberculosis, life-threatening drug-resistant respiratory and skin infections, and other 'bad bugs' routinely making headlines, infectious diseases physicians are applauding Rep. Jim Matheson (D-UT) and Rep. Michael Ferguson (R-NJ) for introducing H.R. 3697, the Strategies To Address Antimicrobial Resistance Act.
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9. Computers help chemists fight emerging infections
   08-19-2007 · EurekAlert!
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10. Einstein researchers' prototype vaccine could provide improved protection against tuberculosis
    08-01-2007 · EurekAlert!
    Using a novel approach, researchers at the Albert Einstein College of Medicine of Yeshiva University have developed a prototype vaccine against tuberculosis, that works better in animal models than the only TB vaccine now available. In this era of multi-drug resistant TB and growing numbers of people with active TB due to coinfection with HIV, the advance could herald a needed breakthrough against one of the world's leading killers.
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