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A twist of fate -- Reprogrammed fibroblasts resemble embryonic stem cells
06-06-2007 · EurekAlert!Stem cell biology takes another exciting leap forward as scientists report that normal tissue cells can be reprogrammed to exhibit many of the properties that are characteristic of embryonic stem cells, including the ability to give rise to multiple cell types and contribute to the germline.
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Keywords: twist, fate, reprogrammed, fibroblasts, resemble, embryonic, stem, cells, fibroblast, cell
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- Reprogrammed fibroblasts identical to embryonic stem cells
06-06-2007 · EurekAlert!
Researchers have manipulated mouse fibroblasts and, without using any eggs or embryos, turned them into cells with such developmental elasticity that they appear identical to embryonic stem cells.
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- Cells take risks with their identities
07-12-2007 · EurekAlert!
Contrary to textbook models, many genes that should be "off" in embryonic stem cells and specialized adult cells remain primed to produce master regulatory proteins, leaving those cells vulnerable to identity changes. The genes encoding the master regulators of cell fate begin making RNA templates for these proteins, though a control mechanism stops them from finishing the job.
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- Simple recipe turns human skin cells into embryonic stem cell-like cells
11-20-2007 · EurekAlert!
A simple recipe -- including just four ingredients -- can transform adult human skin cells into cells that resemble embryonic stem cells, researchers report in an immediate early publication of the journal Cell, a publication of Cell Press. The converted cells have many of the physical, growth and genetic features typically found in embryonic stem cells and can differentiate to produce other tissue types, including neurons and heart tissue, according to the researchers.
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- Reprogrammed adult cells treat sickle-cell anemia in mice
12-06-2007 · EurekAlert!
This is the first proof of principle for using adult cells reprogrammed to an embryonic-stem-cell-like state, combined with gene and cell therapy, for successful disease treatment in mice. Similar "induced pluripotent stem cells" were recently derived with human cells.
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- UCLA stem cell scientists reprogram human skin cells into embryonic stem cells
02-11-2008 · EurekAlert!
UCLA stem cell scientists have reprogrammed human skin cells into cells with the same unlimited properties as embryonic stem cells without using embryos or eggs.
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- New use for stem cells found in war on terrorism
09-25-2007 · EurekAlert!
For more than a decade, Steve Stice has dedicated his research using embryonic stem cells to improving the lives of people with degenerative diseases and debilitating injuries. His most recent discovery, which produces billions of neural cells from a few stem cells, could now aid in national security. In collaboration with the US Naval Research Laboratory, Stice hopes to use his recently developed neural cell kits to detect chemical threats.
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- Scientists overcome obstacles to stem cell heart repair
12-12-2007 · EurekAlert!
Scientists have overcome two significant obstacles on the road to harnessing stem cells to build patches for damaged hearts. Presenting the research at a UK Stem Cell Initiative conference the researchers will explain how they have made significant progress in maturing beating heart cells derived from embryonic stem cells and in developing the physical scaffolding that would be needed to hold the patch in place in the heart in any future clinical application.
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- Gene Key To Taste Bud Development Identified
10-02-2006 · ScienceDaily
Scientists have identified a gene that controls the development of taste buds. The gene, SOX2, stimulates stem cells on the surface of the embryonic tongue and in the back of the mouth to transform into taste buds, according to the researchers. Stem cells are immature cells that can develop into several different cell types depending on what biochemical instructions they receive.
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- Mass. General researchers identify master cardiac stem cell
11-22-2006 · EurekAlert!
Researchers from the Massachusetts General Hospital Cardiovascular Research Center have discovered what appears to be a master cardiac stem cell, capable of differentiating into the three major cell types of the mammalian heart. In a report to appear in the journal Cell, receiving early online release, they describe identifying these progenitor cells in mice, cloning them from embryonic stem cells, and showing that cloned cells can differentiate into cardiac muscle, smooth muscle or endothelial cells.
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- Reprogramming the debate: stem-cell finding alters ethical controversy
11-20-2007 · EurekAlert!
When University of Wisconsin-Madison researchers succeeded in reprogramming skin cells to behave like embryonic stem cells, they also began to redefine the political and ethical dynamics of the stem-cell debate, a leading bioethicist says.
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