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Alzheimer's enzyme acts as a tumor suppressor

06-07-2007 · EurekAlert!

Researchers at Burnham Institute for Medical Research ("Burnham") have provided the first evidence that gamma-secretase, an enzyme key to the progression of Alzheimer's, acts as a tumor suppressor by altering the pathway of epidermal growth factor receptor (EGFR), a potential treatment target for cancer. Expedited to publication online by Proceedings of the National Academy of Sciences, these findings reveal a limitation of targeting gamma-secretase for treatment of Alzheimer's and potentially other diseases.

Keywords: alzheimer, enzyme, acts, tumor, suppressor, act

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JCI table of contents: April 12, 2007
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