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Key molecular signaling switch involved in allergic disease identified
10-29-2006 · EurekAlert!A research team has identified a key enzyme responsible for triggering a chain of events that results in allergic reaction, according to new study findings published online this week in Nature Immunology.
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- Receptor protein appears to be key in breakdown of kidney filtration
12-19-2007 · EurekAlert!
Massachusetts General Hospital researchers have identified a new molecular pathway that appears to be involved in urinary protein loss, an early-stage kidney disease thet affects 100 million people around the world, and is caused by a breakdown in the kidney's filtering structures.
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- Researchers identify unusual molecular switch for common form of advanced breast cancer
11-08-2007 · EurekAlert!
New evidence demonstrates that a novel molecular switch is involved in the development of a common form of advanced breast cancer, known as locally advanced breast cancer. The research, published by Cell Press in the Nov. 9, 2007 issue of Molecular Cell, provides an exciting paradigm shift in the understanding of a key event in breast cancer development and presents new therapeutic opportunities for this deadly disease.
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- Molecular mechanism of common forms of kidney disease identified
08-01-2007 · EurekAlert!
Massachusetts General Hospital researchers have identified a key mechanism underlying proteinuria -- excess protein in the urine which signifies a breakdown in the kidney's filtering process. They have discovered that enzymatic processing of protein called dynamin can cause breakdown of a critical filtering structure called a podocyte, allowing protein to leak out of the bloodstream. The researchers also describe how altered forms of dynamin may be able to block the process and restore kidney function.
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- Lupus gene finding prompts call for more DNA samples
12-02-2007 · EurekAlert!
Wellcome Trust researchers have identified a key gene involved in the disease lupus, which affects around 50,000 people in the UK, mostly women. The lead researcher behind the study has called for more patients to volunteer DNA samples to enable them to further study the underlying causes of the disease.
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- Link identified between Alzheimer's disease and glaucoma
08-06-2007 · EurekAlert!
UK scientists have shown for the first time that key proteins involved in Alzheimer's disease are also implicated in glaucoma, the major cause of irreversible blindness worldwide. Research carried out at the UCL Institute of Ophthalmology and funded by the Wellcome Trust has also shown that novel drugs being trialed for Alzheimer's disease may be used to treat glaucoma.
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- Jefferson scientists uncover key pathway, potential drug targets in autoinflammatory disease
11-12-2007 · EurekAlert!
Molecular biologists at Jefferson's Kimmel Cancer Center in Philadelphia have detailed the cascade of cellular events behind some potentially dangerous autoinflammatory diseases. In doing so, they not only have gained a greater understanding of the disease process, but have also identified new potential drug targets for diseases ranging from arthritis to cancer.
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- Novel regulatory mechanism identified for key tumor suppressor p53
11-15-2006 · EurekAlert!
Collaborating scientists from the Wistar Institute in Philadelphia and the Vienna Biocenter in Austria have identified a novel mechanism involved in normal repression of the p53 protein, perhaps the single most important molecule for the control of cancer in humans. The new molecular pathway described in the study suggests intriguing approaches to diagnosing or intervening in the progression of many types of cancer.
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- Researchers identify protein pathway involved in Parkinson disease development
06-18-2007 · EurekAlert!
Scientists have found a novel signaling pathway in cells that is altered by genetic mutations recently identified in Parkinson disease development. These new findings show how the mutations affect cellular function and could provide a target for drug therapies to treat the disease.
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- Getting to the bottom of memory
01-05-2007 · EurekAlert!
Researchers from the European Molecular Biology Laboratory's (EMBL) Mouse Biology Unit in Monterotondo, Italy, and the Universidad Pablo de Olavide in Sevilla, Spain, now for the first time investigate the molecular basis of memory in living mice. The study, which appears in the current issue of Learning and Memory, identified a molecule that is crucially involved in learning and singled out the signaling pathway through which it affects memory.
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- Molecular differences between early and advanced melanomas could provide new drug targets
03-12-2007 · EurekAlert!
The cell-signaling molecule Akt is a primary trigger that leads malignant melanomas on the skin's surface to begin growing vertically beneath the skin and turn into deadly invasive cancers, scientists have found. Understanding this key molecular difference between radial melanomas that spread on the surface of the skin and melanomas that grow vertically and invasively could provide new targets for the development of drugs to treat individuals with advanced stage melanomas.
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