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Researchers reveal structure of protein altered in autism
06-12-2007 · EurekAlert!As a result of mapping the structure of the protein complex implicated in autism spectrum disorders, a research team led by scientists at the University of California, San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences has discovered how particular genetic mutations affect this complex and contribute to the developmental abnormalities found in children with autism.
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Keywords: researchers, reveal, structure, protein, altered, autism, researcher
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- Molecular mechanism of common forms of kidney disease identified
08-01-2007 · EurekAlert!
Massachusetts General Hospital researchers have identified a key mechanism underlying proteinuria -- excess protein in the urine which signifies a breakdown in the kidney's filtering process. They have discovered that enzymatic processing of protein called dynamin can cause breakdown of a critical filtering structure called a podocyte, allowing protein to leak out of the bloodstream. The researchers also describe how altered forms of dynamin may be able to block the process and restore kidney function.
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- Protein's strength lies in h-bond cooperation
02-14-2008 · EurekAlert!
Researchers in Civil and Environmental Engineering at MIT reveal that the strength of a biological material like spider silk lies in the geometric configuration of structural proteins, and the small clusters of weak hydrogen bonds that work cooperatively to resist force and dissipate energy. This structure makes protein-based materials as strong as steel, even though the hydrogen bonds that hold them together are 100 to 1,000 times weaker than the metallic bonds in steel.
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- Penn researchers discover new target for preventing and treating flu
01-30-2008 · EurekAlert!
Researchers at the University of Pennsylvania School of Medicine have now provided a new strategy for designing drugs that target resistant viral strains of inflenza tupe A by solving the three-dimensional structure of a viral protein called the M2 proton channel. This protein is the molecular receptor for these drugs.
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- Crystal structure enables tailoring of pharmaceuticals against asthma
07-16-2007 · EurekAlert!
Researchers at Karolinska Institutet in Sweden have managed to elucidate the crystal structure of a human membrane protein -- LTC4 synthase -- which has a major influence on the development of asthma. LTC4 synthase is extremely difficult to analyze, and previously only low resolution information has been available on two membrane protein structures from human. The scientists now believe that their work will enable the development of new and better therapeutics against inflammations in the pulmonary tract.
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- Enzyme structure reveals new drug targets for cancer and other diseases
02-14-2008 · EurekAlert!
Researchers now have a clearer understanding of how a key protein controls gene activity and how mutations in the protein may cause disease. The work could provide new avenues to design drugs aimed at cancer, diabetes, HIV, and heart disease.
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- Brown scientists map structure of DNA-doctoring protein complex
12-06-2006 · EurekAlert!
Mobile DNA, which inserts foreign genes into target cells, is a powerful force in the march of evolution and the spread of disease. Working with the lambda virus and E. coli bacteria, Brown University biologists have solved the structure of a six-protein complex critical to performing this gene-grafting surgery. The technique they developed could be used to reveal the structure of other critical protein complexes, landing the work on the cover of Molecular Cell.
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- OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
06-01-2007 · EurekAlert!
Oregon Health & Science University Cancer Institute researchers have identified a protein that is a strong indicator of survival for men with advanced prostate cancer. The C-reactive protein, also known as CRP, is a special type of protein produced by the liver that is elevated in the presence of inflammation.
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- Discovery may pave the way for a new class of diabetes drugs
08-29-2007 · EurekAlert!
A multidisciplinary team led by researchers at the University of California, San Diego has determined the structure of a protein found in cells that shows potential as a target for the development of new drugs to treat diabetes.
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- Tiny device enables wide range of study at liquid-liquid interface
12-18-2006 · EurekAlert!
Researchers at Washington University in St. Louis are putting a different kind of "foursome" together in hopes of someday developing smart materials called biomimetics that mimic nature. Amy Shen, Ph.D., assistant professor of Mechanical and Aerospace Engineering, and her Washington University colleague William F. Pickard, Ph.D., senior professor of Electrical and Systems Engineering, are collaborating with a researcher at Washington State University, and one at Indiana University/Purdue University on understanding a plant protein called forisome.
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- Penn scientists engineer small molecules to probe proteins deep inside cell membrane
03-30-2007 · EurekAlert!
To probe the secrets of inaccessible transmembrane proteins, researchers at the University of Pennsylvania School of Medicine have designed peptides that are able to bind to specific inner regions, using computer algorithms, and information from existing protein sequence and structure databases. This study looks at how the binding of these designed peptides affects the crucial first steps in blood clotting.
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