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Stanford researchers clarify protein's role in multiple sclerosis
06-13-2007 · EurekAlert!A protein found primarily in the lens of the eye could be the critical "tipping point" in the spiral of inflammation and damage that occurs in multiple sclerosis, researchers at the Stanford University School of Medicine report.
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Keywords: stanford, researchers, clarify, protein, role, multiple, sclerosis, researcher, sclerosi
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- 'Junk' DNA now looks like powerful regulator, Stanford researcher finds
04-23-2007 · EurekAlert!
Large swaths of garbled human DNA once dismissed as junk appear to contain some valuable sections, according to a new study by researchers at the Stanford University School of Medicine and the University of California-Santa Cruz. The scientists propose that this redeemed DNA plays a role in controlling when genes turn on and off.
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- Molecule linked to autoimmune disease relapses identified at Stanford
12-03-2006 · EurekAlert!
The ebb and flow of such autoimmune diseases as multiple sclerosis, lupus and rheumatoid arthritis has long been a perplexing mystery to scientists. But new findings from the Stanford University School of Medicine bring scientists closer to solving the puzzle, identifying a molecule that appears to play a central role in these relapses.
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- Jefferson immunology researchers show blood-brain barrier damage could affect MS severity
04-05-2007 · EurekAlert!
Immunology researchers at the Kimmel Cancer Center at Jefferson studying a multiple sclerosis (MS)-like disease in mice have shown that the amount of "damage" to the central nervous system’s protective blood-brain barrier -- in essence, opening it -- almost always correlates to the severity of the disease. The findings can be used for testing potential MS therapies and for better understanding the role of the blood-brain barrier in disease processes.
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- Emory researchers identify signaling protein for multiple myeloma
09-10-2007 · EurekAlert!
Researchers at Emory University's Winship Cancer Institute are the first to discover a mechanism that plays a critical role in the multiple myeloma cell cycle and survival. Their research may result in identification of a new therapeutic target for treating multiple myeloma.
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- Vet medicine researcher examines link between cancer, Down syndrome
02-04-2008 · EurekAlert!
There's new hope for breast cancer research, and it's coming from a very unlikely place. Researchers at the Texas A&M University College of Veterinary Medicine & Biomedical Sciences recently published articles in the journals Molecular and Cellular Biology and Carcinogenesis indicating that a protein long suspected to play a role in Down Syndrome may also contribute to treating this devastating disease.
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- Penn researchers discover new molecular path to fight autoimmune diseases
03-06-2007 · EurekAlert!
Multiple sclerosis, diabetes, and arthritis are among a variety of autoimmune diseases that are aggravated when one type of white blood cell, called the immune regulatory cell, malfunctions. In humans, one cause of this malfunction is when a mutation in a gene called FOXP3 disables the immune cells’ ability to function. Penn researchers have discovered how to modify enzymes that act on the FOXP3 protein, in turn making the regulatory immune cells work better.
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- 'Cars' imaging reveals clues to myelin damage
06-27-2007 · EurekAlert!
Researchers have discovered that calcium ions could play a crucial role in multiple sclerosis by activating enzymes that degrade the fatty sheath that insulates nerve fibers.
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- Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
11-11-2007 · EurekAlert!
An immune system messenger molecule that normally helps quiet inflammation could be an effective tool against multiple sclerosis. Neurology researchers at Jefferson Medical College have found that the protein interkeukin-27 (IL-27) helped block the onset or reverse symptoms in animals with an MS-like disease. The results suggest that IL-27 may someday be part of a therapy to temper over-active immune responses, which are thought to be at the heart of MS.
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- Carbon monoxide protects mice from multiple sclerosis
01-25-2007 · EurekAlert!
Multiple sclerosis (MS) is a chronic inflammatory disorder that causes degeneration of the nerves in the brain and spinal cord, leading to various symptoms including muscle weakness and pain. Using a mouse model of MS (known as EAE), researchers have now shown that increased expression of a protein known as HO-1, as well as administration of carbon monoxide, protects mice from disease.
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- Deactivating protein may protect nerve fibers in MS
04-23-2007 · EurekAlert!
Oregon Health & Science University neuroscientists are eyeing a protein as a potential therapeutic target for multiple sclerosis because de-activating it protects nerve fibers from damage. OHSU researchers have shown that genetically inactivating a protein called cyclophilin D can protect nerve fibers in a mouse model of multiple sclerosis. Cyclophin D is a key regulator of molecular processes in the nerve cell's powerhouse, the mitochondrion, and can participate in nerve fiber death.
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