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Bacteria ferry nanoparticles into cells for early diagnosis, treatment
06-13-2007 · EurekAlert!Researchers at Purdue University have shown that common bacteria can deliver a valuable cargo of "smart nanoparticles" into a cell to precisely position sensors, drugs or DNA for the early diagnosis and treatment of various diseases.
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Keywords: bacteria, ferry, nanoparticles, cells, diagnosis, treatment, nanoparticle, cell, diagnosi
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- Silicon nanoparticles enhance performance of solar cells
08-20-2007 · EurekAlert!
Placing a film of silicon nanoparticles onto a silicon solar cell can boost power, reduce heat and prolong the cell's life, researchers now report.
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- Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas
09-10-2007 · EurekAlert!
A new study provides evidence that noncoding RNAs and interactions between noncoding genes play a much greater role in human cancer than was previously understood. The research, published by Cell Press in the September issue of the journal Cancer Cell, may be useful for identifying tumor-specific signatures associated with diagnosis, prognosis and treatment of cancer.
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- Extracellular protein sensitizes ovarian cancer cells to chemotherapy
12-10-2007 · EurekAlert!
Scientists have uncovered critical new details about the mechanisms that modulate the response of ovarian cancer cells to chemotherapy. The research, published by Cell Press in the December issue of Cancer Cell, helps to explain why many patients develop resistance to the taxane class of drugs and may lead to improved treatment of ovarian cancer.
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- Gold nanoparticles may pan out as tool for cancer diagnosis
07-31-2007 · EurekAlert!
When it comes to searching out cancer cells, gold may turn out to be a precious metal. Purdue University researchers have created gold nanoparticles capable of identifying marker proteins making the tiny particles a potential tool to better diagnose and treat breast cancer.
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- Brown scientists map structure of DNA-doctoring protein complex
12-06-2006 · EurekAlert!
Mobile DNA, which inserts foreign genes into target cells, is a powerful force in the march of evolution and the spread of disease. Working with the lambda virus and E. coli bacteria, Brown University biologists have solved the structure of a six-protein complex critical to performing this gene-grafting surgery. The technique they developed could be used to reveal the structure of other critical protein complexes, landing the work on the cover of Molecular Cell.
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- Assumption of function not always correct
05-01-2007 · EurekAlert!
A protein called RecQ takes on a totally opposite function in the bacteria Escherichia coli to the one it fulfills in yeast and in humans, indicating that people seeking to understand the role of different forms in human cells and disease need to consider both possibilities, said researchers from Baylor College of Medicine in a report in the current issue of Molecular Cell.
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- Tumor-reactive T cells boosted by hematopoietic stem cell transplantation
02-01-2007 · EurekAlert!
Treatment for skin cancer by infusion of tumor-reactive T cells requires patients to be pre-treated with agents that transiently decrease the number of immune cells (nonmyeloablative agents). A study in mice now indicates that pre-treatment with more intense immune cell-depleting strategies (known as myeloablative strategies) and a hematopoietic stem cell transplant enables infused tumor-reactive CD8+ T cells to increase in number more than pre-treatment with nonmyeloablative agents, and this correlates with increased tumor regression.
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- 2 heads are better than 1: 2 dysfunctional DNA repair pathways kill tumor cells
04-12-2007 · EurekAlert!
Individuals who inherit one mutant copy of any one of about 12 genes that make the proteins of the Fanconi Anemia pathway are at increased risk of developing cancer. This occurs when the remaining "good" copy of the gene becomes mutated in a specific cell type. However, hope of a new treatment for these cancers has now been provided by a new study indicating that inhibiting the protein ATM can kill these cancer cells.
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07-11-2007 · EurekAlert!
Researchers from the University of Pittsburgh School of Medicine report a significant new advance in the search for an effective treatment for human liver cancer. Using a newly available monoclonal antibody, they demonstrated dramatic reductions in tumor cell proliferation and survival in human and mouse hepatocellular cancer cell lines. This finding has significant implications not only for the treatment of liver cancer but for a number of different types of cancer.
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- Clemson scientists shed light on molecules in living cells
08-21-2007 · EurekAlert!
Clemson University chemists have developed a method to dramatically improve the longevity of fluorescent nanoparticles that may someday help researchers track the motion of a single molecule as it travels through a living cell. The chemists are exploiting a process called "resonance energy transfer."
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