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Penn researchers link cell's protein recycling systems
06-13-2007 · EurekAlert!Researchers have discovered a molecular link between the cell's two major pathways for breaking down proteins and have succeeded in using this link to rescue neurodegenerative diseases in a simple animal model.
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Keywords: penn, researchers, link, cell, protein, recycling, systems, researcher, system
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- An AIDS-related virus reveals more ways to cause cancer, Penn researchers find
10-08-2007 · EurekAlert!
Researchers have shed new light on how Kaposi's Sarcoma-associated Herpes Virus subverts normal cell machinery to cause cancer. A KSHV protein called latency-associated nuclear antigen (LANA) helps the virus hide out from the immune system in infected cells. When LANA takes the place of other proteins that control cell growth, it can cause uncontrolled cell replication.
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- Certain diseases, birth defects may be linked to failure of protein recycling system
12-20-2007 · EurekAlert!
A group of signaling proteins known as Wnt -- which help build the human body's skin, bone, muscle and other tissues -- depend on a complex delivery and recycling system to ensure their transport to tissue-building cell sites. Failure of this system may be a mechanism of cancer, heart disease or birth defects related to Wnt proteins, according to researchers at Cincinnati Children's Hospital Medical Center.
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- Researchers led by Penn vet uncover the delicate protein balance behind the immune system response
12-10-2007 · EurekAlert!
A team of researchers from the University of Pennsylvania School of Veterinary Medicine has identified the protein interactions involved in the immune system process that fights infection yet, in certain inflammatory diseases, runs amok and attacks friendly tissue.
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- Researchers design pulsed mircrojet system to deliver protein drugs without pain or bruising
03-06-2007 · EurekAlert!
A team of UCSB researchers, in collaboration with colleagues from UC Berkeley and StrataGent Life Sciences, of Los Gatos, Calif., has designed a novel pulsed microjet system engineered to deliver protein drugs into the skin without the pain or bruising that deeper penetration injection systems cause. The research was published online today in the Proceedings of the National Academy of Sciences.
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- Researchers develop marker that identifies energy-producing centers in nerve cells
02-01-2007 · EurekAlert!
A protein that causes coral to glow is helping researchers at the University of Maryland School of Medicine to light up brain cells that are critical for the proper functioning of the central nervous system. This fluorescent marker protein may shed light on brain cell defects believed to play a role in various neurological diseases.
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- Penn researchers discover new molecular path to fight autoimmune diseases
03-06-2007 · EurekAlert!
Multiple sclerosis, diabetes, and arthritis are among a variety of autoimmune diseases that are aggravated when one type of white blood cell, called the immune regulatory cell, malfunctions. In humans, one cause of this malfunction is when a mutation in a gene called FOXP3 disables the immune cells’ ability to function. Penn researchers have discovered how to modify enzymes that act on the FOXP3 protein, in turn making the regulatory immune cells work better.
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- Major link in brain-obesity puzzle found
01-29-2007 · EurekAlert!
A single protein in brain cells may act as a linchpin in the body's weight-regulating system, playing a key role in the flurry of signals that govern fat storage, sugar use, energy balance and weight, researchers report. And although it's far too early to say how this protein could be useful in fighting obesity, the finding gives scientists an important system to target in future research and the development of anti-obesity medications.
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- Enzyme synergy shown to perpetuate sleeping sickness
10-18-2007 · EurekAlert!
The pathogenesis of the parasite African trypanosome (T. brucei) has been linked to a key protein switch, detailed in a new study by researchers at the University of Iowa and the Veterans Affairs Medical Center of Iowa City, led by Dr. John Donelson. The study, published in PLoS Pathogens, explains how two enzymes enable the cell's surface to remodel itself in order to thwart the immune system of carrier tsetse flies.
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- Penn scientists engineer small molecules to probe proteins deep inside cell membrane
03-30-2007 · EurekAlert!
To probe the secrets of inaccessible transmembrane proteins, researchers at the University of Pennsylvania School of Medicine have designed peptides that are able to bind to specific inner regions, using computer algorithms, and information from existing protein sequence and structure databases. This study looks at how the binding of these designed peptides affects the crucial first steps in blood clotting.
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- Researchers double cell phone memory through software alone
09-26-2007 · EurekAlert!
Computer engineers at Northwestern University and NEC Laboratories America, Inc. are the first to do what many thought impossible -- they have developed technology that doubles the usable memory on cell phones and other embedded systems without any changes to hardware or applications. The improvement was made in the operating system software alone. This innovation is featured in millions of new NEC-manufactured smartphones that first hit shelves in Japan this summer.
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