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Study could impact noninvasive treatment of cancer tumors

Ram Devireddy, assistant professor of mechanical engineering at LSU, recently co-authored an article with Todd Monroe, assistant professor of biological and agricultural engineering, investigating the complex effects of nanoparticles on cell freezing. The report was published in the prestigious journal Nanotechnology.

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Keywords: study, impact, noninvasive, treatment, cancer, tumors, tumor

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1. Therapeutic peptide frees the protein p73 to kill tumor cells
   03-08-2007 · EurekAlert!
   p53 suppresses tumor development by inducing tumor cell death. However, targeting p53 for the treatment of cancer is confounded by the fact that genetic mutations cause loss or inactivation of p53 in approximately 50 percent of human cancers. Now, a new study indicates that targeting the p53-related protein p73 in mice induces the regression of established tumors of human origin, leading to the suggestion that p73 might be a viable target for developing anticancer therapeutics.
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2. Study shows blood markers can help choose best dose for antiangiogenic drugs
   10-25-2007 · EurekAlert!
   Scientists at Sunnybrook have new information that may help to improve the use of anti-cancer drugs designed to block the growth of new blood vessels in tumors, a process called angiogenesis that is critical to tumor growth. While these antiangiogenic drugs are effective, at present there are no reliable methods for determining whether they are working, if the right dose is used, or if a patient will benefit from treatment.
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3. Treatment capitalizes on unique qualities of radioisotope to prolong lives of brain tumor patients
   01-30-2008 · EurekAlert!
   In a study to determine safe dosages of the isotope astatine-211 for patients with recurring brain tumors, researchers were pleasantly surprised to find that not only was the isotope's potency sufficient to kill residual cancer cells without damaging sensitive healthy brain cells, but the patients experienced longer survival rates.
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4. 2 microRNAs promote spread of tumor cells
   01-28-2008 · EurekAlert!
   Scientists at The Wistar Institute and their colleagues have identified two microRNAs that promote tumors' deadly spread. One of the miRNAs may provide an early warning of metastatic breast cancer and the need for aggressive treatment. In a study to be published Feb. 1 in Nature Cell Biology that is available online, the researchers describe how two miRNAs transformed non-invasive human breast cancer cells into cells that rapidly metastasized in cell cultures and mice.
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5. Cancer treatment targets tumor blood supply in patients
   03-02-2007 · EurekAlert!
   An antibody called J591 specifically targets an antigen found in high amounts on both prostate tumors and on blood vessels of all solid tumors, according to a study by researchers at NewYork-Presbyterian Hospital/Weill Cornell Medical Center.
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6. Study offers innovative profile of enzyme that aids tumor growth
   10-20-2006 · EurekAlert!
   Using an innovative profiling strategy, scientists at the Scripps Research Institute have characterized an enzyme that is "highly elevated" in aggressive human tumor cells. When the enzyme, KIAA1363, was inactivated, it impaired tumor growth and migration in both ovarian and breast cancer cells, suggesting that inhibitors of this enzyme may prove valuable in the treatment of multiple types of cancer.
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7. Intravenous chemoradiation effective for inoperable head, neck cancer; easier for patients, doctors
   11-06-2006 · EurekAlert!
   Chemoradiation (radiation and chemotherapy given at the same time) given through a needle or tube inserted into a vein (intravenous) is as effective as treatment given directly to the tumor through a tube inserted into an artery (intra-arterial) for patients with inoperable head and neck cancer, according to a randomized study presented at the plenary session November 6, 2006, at the American Society for Therapeutic Radiology and Oncology's 48th Annual Meeting in Philadelphia.
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8. Decoding gene expression in cancer tumors using noninvasive imaging
   05-21-2007 · EurekAlert!
   By correlating images of cancerous liver tissue with gene expression patterns, a research team led by a radiologist at the University of California, San Diego School of Medicine has developed tools that may some day allow physicians to view a CT image of a cancer tumor and discern its genetic activity.
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9. Scientists follow familiar TRAIL to new cancer therapy
   07-09-2007 · EurekAlert!
   A new study identifies a combination therapy that may sensitize human cancer cells to a promising treatment currently being used in clinical trials. The research, published in the July issue of the journal Cancer Cell, published by Cell Press, provides a pharmacological method for enhancing the potency and effectiveness of a tumor necrosis factor death receptor ligand against a variety of human cancers.
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10. Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas
    09-10-2007 · EurekAlert!
    A new study provides evidence that noncoding RNAs and interactions between noncoding genes play a much greater role in human cancer than was previously understood. The research, published by Cell Press in the September issue of the journal Cancer Cell, may be useful for identifying tumor-specific signatures associated with diagnosis, prognosis and treatment of cancer.
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