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Bone marrow microenvironment can contribute to blood cell disorder
06-14-2007 · EurekAlert!Disorders of blood cells may begin in the biological environment where the cells develop, not just with the cells themselves, according to a study from researchers at the Massachusetts General Hospital and the Peter MacCallum Cancer Center in Melbourne, Australia.
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Keywords: bone, marrow, microenvironment, contribute, blood, cell, disorder
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- A new way to boost red blood cell numbers
01-10-2008 · EurekAlert!
A common treatment for anemia is administration of recombinant erythropoietin, a hormone that stimulates the production of rbc precursors by the bone marrow. Unfortunately, many patients with anemia do not respond to treatment with Epo. However, a new study in mice has indicated that the protein Gas6 might have valuable therapeutic potential for the treatment of individuals with anemia who fail to respond to treatment with Epo.
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- Adult stem cell application effective in treatment of peripheric vascular disease
01-24-2008 · EurekAlert!
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- Studies attribute recent increase in multiple myeloma survival to novel therapies
11-01-2007 · EurekAlert!
Multiple myeloma is one of the most common and devastating bone marrow cancers in the US, but survival rates have risen dramatically over the past decade. Recent analyses suggest that this trend may be attributed to new types of drugs and aggressive therapeutic interventions such as stem cell transplantation, according to the results of two studies prepublished online in Blood, the official journal of the American Society of Hematology.
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- Stretching bone marrow stem cells pushes them towards becoming blood vessel
10-23-2006 · EurekAlert!
When stretched, a type of adult stem cell taken from bone marrow can be nudged towards becoming the type of tissue found in blood vessels, according to a new study by UC Berkeley bioengineers. The findings highlight the importance of mechanical forces in stem cell differentiation.
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- A faster way to recover from chemotherapy and marrow transplant
06-20-2007 · EurekAlert!
Researchers at Children's Hospital Boston report finding a practical way to increase stem cells in blood, suggesting a possible treatment to help patients recover from chemotherapy or bone marrow transplant for cancer, regaining immune function more quickly. The discovery, reported in the June 21 Nature and made possible through high-volume drug screening in fish, marks the first time stem-cell production has been induced by a small-molecule drug.
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- Unique role for blood formation gene identified
09-12-2007 · EurekAlert!
All blood cell production in adults depends on the steady work of a vital gene that if lost results in early bone marrow failure, Dartmouth Medical School cancer geneticists have found. Their research reveals an unexpected role for the gene in sustaining the adult blood-forming system, and opens novel strategies for targeting the gene, which is often involved in a type of childhood leukemia.
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- Insights into anemia control in dialysis patients
07-11-2007 · EurekAlert!
Anemia is one of the most frequent complications of hemodialysis, and its correction is an important factor in restoring a tolerable quality of life to dialysis-dependent patients. Treatment with drugs called erythropoiesis-stimulating agents (ESAs), which stimulate the bone marrow to produce red blood cells, have been a major advance in the treatment of the anemia (low levels of red blood cells or hemoglobin, which carries oxygen in the blood) in chronic kidney disease (CKD).
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- Researchers develop novel method for treatment of sickle cell disease
11-07-2006 · EurekAlert!
Virginia Commonwealth University researchers have developed a unique anti-sickling agent that may one day be effective in treating sickle cell disease, a painful and debilitating genetic blood disorder that affects approximately 80,000 Americans.
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- There goes the neighborhood: Vascular niche nurtures brain tumor stem cells
01-16-2007 · EurekAlert!
New research published in the January 2007 issue of the journal Cancer Cell, published by Cell Press, reveals that small blood vessels associated with brain tumors orchestrate a distinct microenvironment that is critical for maintaining cancer stem cells (CSCs). Importantly, antiangiogenic drugs that disrupt this microenvironment reduce the CSC population and arrest tumor growth.
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- Type of stem cell found to reside in transplanted lungs
03-08-2007 · EurekAlert!
A new study involving a type of stem cells from the lungs of transplant patients demonstrates for the first time that these progenitor cells reside in adult organs and are not derived from bone marrow, which leads to the possibility that the cells may be able to help with the rejection of donated organs and with various kinds of lung disease.
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