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Analysis of breast-cancer gene role offers promising target for drugs to stop or slow progression of disease

10-30-2006 · UT Southwestern Medical Center

Researchers at UT Southwestern Medical Center have for the first time described how multiple copies of a gene are responsible for metastases in early-stage breast cancer and poor prognosis for patients.

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Analysis of breast-cancer gene role offers promising target
10-30-2006 · EurekAlert!
Researchers at UT Southwestern Medical Center have for the first time described how multiple copies of a gene are responsible for metastases in early-stage breast cancer and poor prognosis for patients.
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Researchers at the Kimmel Cancer Center at Jefferson have identified a protein that they say is key to helping a quarter of all breast cancers spread. The finding, reported online the week of April 9, 2007, in the journal Proceedings of the National Academy of Sciences, could be a potential target for new drugs aimed at stopping or slowing the growth and progression of breast cancer.
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10-11-2007 · EurekAlert!
A tumor-blocking protein previously implicated in prostate and breast cancer development may also be behind the most aggressive type of pancreatic cancer. Researchers have discovered that the protein pp32 -- which normally applies the brakes on a cancer-causing gene -- is missing in an aggressive form of pancreatic cancer. Though the work is preliminary, the scientists say, the absent protein could eventually become a marker for the disease and a potential drug target.
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Jefferson scientists find tumor suppressor gene protects against pre-cancerous development
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When a key gene called 14-3-3zeta is silenced, lung cancer cells can't survive on their own, researchers have found. The gene is a potential target for selective anticancer drugs.
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Genomic 'firestorms' underlie aggressive breast cancer progression
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Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging
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Discovery of an HIV inhibitor in human blood points to new drug class
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