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How enzymes work: UB chemists publish a major discovery
06-19-2007 · EurekAlert!In a publication selected as a "2007 Hot Article" by the journal Biochemistry, University at Buffalo chemists report the discovery of a central mechanism responsible for the action of the powerful biological catalysts known as enzymes.
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Keywords: enzymes, work, chemists, publish, major, discovery, enzyme, chemist
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- Translating form into function
07-01-2007 · EurekAlert!
In the last 40 years, scientists have perfected ways to determine the knot-like structure of enzymes, but they've been stumped trying to translate the structure into an understanding of function -- what the enzyme actually does in the body. This puzzle has hurt drug discovery, since many of the most successful drugs work by blocking enzyme action. Now, in an expedited article in Nature, researchers show that a solution to the puzzle is finally in sight.
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- Self-assembling nano-ice discovered at UNL -- Structure resembles DNA
12-11-2006 · EurekAlert!
UNL chemist Xiao Cheng Zeng and his team discovered double helixes of ice molecules that resemble the structure of DNA and self-assemble under high pressure inside carbon nanotubes. This discovery could have major implications for scientists in other fields who study the protein structures that cause diseases such as Alzheimer's and bovine spongiform ecephalitis. It could also help guide those searching for ways to target or direct self-assembly in nanomaterials.
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- Carnegie Mellon U. chemists advance organic semiconductor processing
06-26-2007 · EurekAlert!
Any machinist will tell you that a little grease goes a long way toward making a tool work better. And that may soon hold true for plastic electronics as well. Carnegie Mellon University chemists have found that grease can make some innovative plastics vastly better electrical conductors. This discovery, published June 25 in Advanced Materials, outlines a process that could become widely adopted to produce the next generation of tiny transistor switches.
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- Major breakthrough in understanding how HIV interferes with infected cell division
07-12-2007 · EurekAlert!
Dr. Йric A. Cohen, a researcher at the IRCM, and his team, will publish on Friday, July 13, in PLoS Pathogens a discovery that could lead to the development of a new class of drugs to combat HIV.
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- Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
07-31-2007 · EurekAlert!
Working with human colorectal cancer cells, a University of Minnesota team, led by cancer biologists Zigang Dong and Ann Bode, has found the potential culprit among a network of enzymes that relay signals inside cells to regulate such functions as cell growth, cancer development and programmed cell death. The work suggests that drugs designed to disable the enzyme, known as TOPK, could have anticancer benefits. The study appears in the July issue of the journal Gastroenterology.
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- Using catalysts to stamp nanopatterns without ink
09-26-2007 · EurekAlert!
Using enzymes from E. coli bacteria, Duke University chemists and engineers have introduced a hundred-fold improvement in the precision of features imprinted to create microdevices such as labs-on-a-chip.
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- A discovery that may lessen a health disparity
04-17-2007 · EurekAlert!
Mayo Clinic Cancer Center scientists, in collaboration with Chinese researchers, have isolated an enzyme that could be used to predict survival and recurrence rates for nasopharyngeal cancer -- a common cancer affecting people from Southeast Asia.
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- Gene variants may help to distribute the work of evolution between men and women
01-31-2008 · EurekAlert!
deCODE scientists today report the discovery of two common, single-letter variants in the sequence of the human genome that regulate one of the principle motors of evolution. Yet remarkably, the versions of the SNPs that increase recombination in men decrease it in women, and vice versa.
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- Night of the living enzyme
11-28-2006 · EurekAlert!
Inactive enzymes entombed in tiny honeycomb-shaped holes in silica -- nano-chambers that mimic conditions in living cells -- can spring to life, scientists discovered while attempting salvaging enzymes that had been in a refrigerator long past their expiration date. The finding opens up new possibilities for exploiting these enzyme traps in food processing, decontamination, biosensor design and any other pursuit that requires controlling catalysts and sustaining their activity.
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- Chemical switch triggers critical cell activities
01-16-2007 · EurekAlert!
The freeze-frame image of a molecular relay race, in which one enzyme passes off a protein like a baton to another enzyme, has solved a key mystery to how cells control some vital functions, according to investigators at St. Jude Children's Research Hospital. A report on this work appears in the January 14 advanced online publication issue of Nature.
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