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Analysis of breast-cancer gene role offers promising target
10-30-2006 · EurekAlert!Researchers at UT Southwestern Medical Center have for the first time described how multiple copies of a gene are responsible for metastases in early-stage breast cancer and poor prognosis for patients.
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Similar news on "Analysis of breast-cancer gene role offers promising target":
- Analysis of breast-cancer gene role offers promising target for drugs to stop or slow progression of disease
10-30-2006 · UT Southwestern Medical Center
Researchers at UT Southwestern Medical Center have for the first time described how multiple copies of a gene are responsible for metastases in early-stage breast cancer and poor prognosis for patients.
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- Breast Cancer Lead: Overactive gene is linked to disease
06-16-2007 · Science News Online
A mutated gene that's overly active in breast cancer cells could offer a new target for cancer drugs.
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- Linchpin gene may be useful target for new breast cancer therapies
09-15-2007 · EurekAlert!
University of Iowa researchers have discovered a gene that plays a linchpin role in the ability of breast cancer cells to respond to estrogen. The finding may lead to improved therapies for hormone-responsive breast cancers, and may explain differences in the effectiveness of current treatments.
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- Jefferson scientists find tumor suppressor gene protects against pre-cancerous development
11-01-2006 · EurekAlert!
Cell biologists have provided further evidence that a gene thought to play a role in suppressing tumors actually protects against the development of pre-cancerous cell growth as well. The researchers say that the gene, caveolin-1, which they found in two major types of breast cells, could be a potential target for future drugs aimed at preventing breast cancer. The work also suggests a potentially important role of the tumor "microenvironment" in the cancerous process.
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- New 'knock-out' gene model provides molecular clues to breast cancer
09-05-2007 · EurekAlert!
New insights into the role of estrogen receptor in mammary gland development may help scientists better understand the molecular origin of breast cancer, according to new research from the University of Cincinnati.
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- Breast cancer susceptibility gene predicts outcome and response to treatment in lung cancer
09-25-2007 · EurekAlert!
Researchers have found that the breast cancer susceptibility gene, BRCA1, plays a significant role in nonsmall cell lung cancer. They told the European Cancer Conference in Barcelona that not only can it be used to predict outcome for patients with NSCLC, but it may also prove to be a valuable tool in choosing the best therapy for them.
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- BRCA1 mutation linked to breast cancer stem cells
01-31-2008 · EurekAlert!
A new study may explain why women with a mutation in the BRCA1 gene face up to an 85 percent lifetime risk of breast cancer. Researchers from the University of Michigan Comprehensive Cancer Center found that BRCA1 plays a role in regulating breast stem cells, the small number of cells that might develop into cancers.
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- Experimental technique at GUMC offers real-time analysis of breast cancer biopsies
11-13-2007 · EurekAlert!
A sophisticated microscope that offers a "real-time" 3-D analysis of tissue samples might, in the future, reduce the number of needle biopsies traditionally needed from women suspected of having breast cancer, according to recent research published at Georgetown University Medical Center's Lombardi Comprehensive Cancer Center.
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- Zebrafish: It's not your parents' lab rat
07-30-2007 · EurekAlert!
Developmental biologists at Rice University have found that a gene called LMO4, which is known to play roles in both cell reproduction and in breast cancer, also plays a role in neurological development. By both knocking out and overexpressing the gene in zebrafish, the scientists determined that LMO4 independently regulates two other genes that are involved with the development of the forebrain and eyes. The results are slated to appear in the journal Developmental Biology.
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- Study shows liver an excellent target for cancer gene therapy using viral vectors
02-14-2007 · EurekAlert!
A featured paper in the Feb. 14 issue of Nature Cancer Gene Therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors, based upon a fundamental new understanding of the differences between cancerous and normal liver cells. The findings signal a new way to treat cancers that have spread to the liver, such as metastatic cancers of the colon and breast.
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