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MRSA vaccine shows promise in mouse study

10-30-2006 · EurekAlert!

By combining the four bacterial surface proteins that generate the strongest immune response in mice, researchers at the University of Chicago have created a vaccine that significantly protects immunized animals from multiple disease-causing, drug-resistant strains of Staphylococcus aureus, the most common cause of hospital-acquired infections and a rapidly spreading source of community-associated illness.

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  1. Staph vaccine shows promise in mouse study
    10-30-2006 · EurekAlert!
    By combining four proteins of Staphylococcus aureus that individually generated the strongest immune response in mice, scientists have created a vaccine that significantly protects the animals from diverse strains of the bacterium that cause disease in humans. A report describing the University of Chicago study, funded by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, appears online this week in the Proceedings of the National Academy of Sciences.
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  2. OHSU Cancer Institute shows findings of immunotherapy vaccine in prostate cancer patients
    06-02-2007 · EurekAlert!
    The study showed that sipuleucel-T did not significantly delay the time it took for a patient's PSA to reach a value of 3 ng/ml, the primary endpoint of the study, but it did show a prolongation in prostate-specific antigen doubling time (PSADT).
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  3. Vaccine shows promise in preventing mono
    12-10-2007 · EurekAlert!
    A new study suggests that a vaccine targeting Epstein-Barr virus may prevent infectious mononucleosis, commonly known as "mono" or "glandular fever." The study is published in the Dec. 15 issue of the Journal of Infectious Diseases, now available online.
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  4. Novel MS drug shows promise in 2 lethal leukemias
    08-28-2007 · EurekAlert!
    A new study suggests that an experimental drug being tested for the treatment of multiple sclerosis and to prevent organ rejection might also help people with certain deadly forms of chronic and acute leukemia. The laboratory and animal study focused on the drug, called fingolimod. Researchers said it might help patients with advanced chronic myelogenous leukemia or acute lymphocytic leukemia, and whose cancer cells show a particular genetic change called the Philadelphia chromosome.
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  5. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinson's symptoms
    08-13-2007 · EurekAlert!
    New evidence indicates that the loss of two types of brain cells -- not just one as previously thought -- may trigger the onset of symptoms associated with Parkinson's disease. The evidence, based on mouse models, shows a link between the loss of both norepinephrine and dopamine neurons and the delayed onset of symptoms associated with Parkinson's disease. It was originally thought that the loss of only dopamine neurons triggered symptoms. Dopamine is a neurotransmitter critical for coordinating movement.
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  6. A longer-living, healthier mouse that could hold clues to human aging
    10-22-2007 · EurekAlert!
    A study by scientists at UCL shows that mice lacking the insulin receptor substrate-1 are more resistant to aging than normal mice. The research adds to a growing body of work showing the importance of insulin signaling pathways as an aging mechanism in mammals -- and potentially humans.
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  7. Study of gene transfer for erectile dysfunction shows promise
    11-30-2006 · EurekAlert!
    The first human study using gene transfer to treat erectile dysfunction (ED) shows promising results and suggests the potential for using the technology to treat overactive bladder, irritable bowel syndrome and asthma, according to the researchers.
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  8. Chronic HIV-1 infection frequently fails to protect against superinfection
    11-15-2007 · EurekAlert!
    Natural HIV-1 infection does not always elicit a protective immune response, according to a new study published Nov. 16 in PLoS Pathogens. The team of researchers show how HIV-1 vaccines may not be as reliable against superinfection as once thought. This study suggests that immune responses found in natural HIV-1 infection may not be the best path to an effective HIV-1 vaccine.
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  9. An Alzheimer's vaccine?
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  10. Uncommon cancer gets start in muscle cells
    04-28-2007 · Science News Online
    Synovial sarcoma, a cancer thought to arise from joint tissue, actually forms in nascent muscle cells, a mouse study shows.
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