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Three new lung tumor subtypes identified in DNA profiling study
10-30-2006 · EurekAlert!A new study has identified three subtypes of non-small-cell lung cancer tumors, a finding that may provide valuable clinical information about patient survival in early- or late-stage disease, how likely the cancer is to spread and whether the tumor will prove resistant to chemotherapy.
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Keywords: lung, tumor, subtypes, identified, dna, profiling, study, subtype
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- Gene profiling predicts resistance to breast cancer drug Herceptin
02-20-2007 · EurekAlert!
Using gene chips to profile tumors before treatment, researchers at Harvard and Yale Universities found markers that identified breast cancer subtypes resistant to Herceptin, the primary treatment for HER2-positive breast cancer. They say this advance could help further refine therapy for the 25 to 30 percent of breast cancer patients with this class of tumor.
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- Susceptibility to Crohn's disease -- an important new clue
04-20-2007 · EurekAlert!
Crohn's disease is a chronic relapsing inflammatory disorder of the intestinal tract that affects an estimated 0.15 percent of people in the developed world. In a genome-wide association study with more than 300,000 single nucleotide polymorphisms -- DNA sequence variations occurring when a single nucleotide in the genome differs between members of a species -- Cйcile Libioulle et al. identified a new susceptibility locus for Crohn's disease.
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- Genes set scene for metastasis
04-11-2007 · EurekAlert!
Biologists at Memorial Sloan-Kettering Cancer Center have identified a set of genes expressed in human breast cancer cells that work together to remodel the network of blood vessels at the site of the primary tumor. These genes were also found to promote the spread of breast cancer to the lungs. The study, conducted in mice and reported in this week's Nature, helps to explain how cancer metastasis can occur and highlights targets for therapeutic treatment.
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- Study finds regions of DNA that appear linked to autistic spectrum disorders
05-09-2007 · EurekAlert!
Using an innovative statistical approach, a research team from Washington University School of Medicine in St. Louis and the University of California, Los Angeles, has identified two regions of DNA linked to autism. They found the suspicious DNA with a much smaller sample of people than has been used traditionally in searches for autism genes.
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- Micro molecules can identify pancreatic cancer
01-10-2007 · EurekAlert!
A pattern of micro molecules can distinguish pancreatic cancer from normal and benign pancreatic tissue, new research suggests. The study examined human pancreatic tumor tissue and compared it to nearby normal tissue and control tissue for levels of microRNA (miRNA). It identified about 100 different miRNAs that are present usually at very high levels in the tumor tissue.
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- Brain tumors coax important support from nearby immune system cells
04-11-2007 · EurekAlert!
Developing brain tumors can coax assistance from nearby cells known as microglia, according to a new study from scientists at Washington University School of Medicine in St. Louis. The researchers have identified one protein made by microglia that helps accelerate tumor growth and are looking for others.
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- Genomic profiling of lung tumors helps doctors choose most effective treatment
09-28-2007 · EurekAlert!
Determining the genetic profile of a particular lung tumor can help clinicians make the crucial decision about which chemotherapy treatment to try first.
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- DMP1 deletion cooperates with oncogenic K-ras in lung cancer
10-15-2007 · EurekAlert!
Scientists have identified the transcription factor DMP1 as a pivotal tumor suppressor for both human and mouse lung cancers, especially in carcinomas that exhibit intact Arf-p53 pathways. The research, published by Cell Press in the October 2007 issue of Cancer Cell, may lead to development of new drug therapies for lung cancer.
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- CD200 stifles anti-tumor immunity
11-15-2007 · EurekAlert!
Prognosis for individuals with metastatic melanoma is not good. Therapeutic strategies to enhance the immune response have some clinical benefit, however, most patients eventually succumb to progressive disease, in part because their dendritic cells fail to sustain an effective anti-tumor immune response. A new in vitro study using human MM tumor cells has identified one mechanism that represses DC function in MM -- expression of high levels of CD200 by the MM tumor cells.
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- Multicenter study nets new lung tumor-suppressor gene
08-05-2007 · EurekAlert!
Collaborating scientists in Boston and North Carolina have found that a particular gene can block key steps of the lung cancer process in mice. The researchers report in the journal Nature that LKB1 is not only a "tumor-suppressor" gene for nonsmall cell lung cancer in mice, it also may be more powerful than other, better-known suppressors. The study will be published on the journal's Web site on Aug. 5.
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