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Study finds estrogen therapy gives aging brain cells a boost

06-25-2007 · EurekAlert!

Cyclical, long-term estrogen injections protected brain cells from age-related deterioration, according to a new study conducted at Mount Sinai School of Medicine. The study suggests that age is a factor in estrogen treatment and sheds light on the intricate relationship between mind, age, and hormones. The study will be published in the online edition of Proceedings of the National Academy of Sciences during the week of June 25.

Keywords: study, estrogen, therapy, aging, brain, cells, boost, cell

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Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
08-30-2007 · EurekAlert!
A drug that shuts down a critical cell-signaling pathway in the most common and aggressive type of adult brain cancer successfully kills cancer stem cells thought to fuel tumor growth and help cancers evade drug and radiation therapy, a Johns Hopkins study shows.
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Method to prevent hemorrhagic complications of thrombolytic therapy of blood clots is discovered
07-02-2007 · EurekAlert!
The now reported study led by Dr. Perttu J. Lindsberg from the Helsinki University Central Hospital investigated thrombolytics-related brain hemorrhage formation in an experimental stroke model in rats. It found that, in addition to the clot lysing effect, the drug used for this purpose, alteplase (recombinant tissue plasminogen activator) also possesses proinflammatory properties and activates and degranulates mast cells, a kind of tissue-based immune cell.
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Replacing the cells lost in Parkinson disease
12-03-2007 · EurekAlert!
Parkinson disease is caused by the progressive degeneration of dopamine brain cells. Replacing these cells is considered a promising therapeutic strategy. Although DA cell-replacement therapy by transplantation of human fetal mesencephalic tissue has shown promise, limited tissue availability means other sources of these cells are needed. A recent study has described one new source for DA cells that provided marked benefit when transplanted into mice with a PD-like disease.
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CTRC enrolls first patients in Novel Phase II study for sarcoma -- Living virus destroys cancer cell
07-24-2007 · EurekAlert!
The Cancer Therapy & Research Center Institute for Drug Development, in collaboration with Oncolytics Biotech Inc., a biotechnology company, has enrolled the first two patients in a new Phase II clinical study for patients with various types of sarcomas that have metastasized to the lung. The novel anti-cancer therapy, REOLYSIN, is a living virus, not a chemotherapy drug, that is toxic to cancer cells but not harmful to normal cells.
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Revealing estrogen's secret role in obesity
08-20-2007 · EurekAlert!
Research on the effects of the female sex hormone estrogen in the brain lend credence to what many women have suspected about the hormonal changes that accompany aging: Menopause can make you fat. In animal experiments, researchers showed how estrogen receptors in the brain serve as a master switch to control food intake, energy expenditure and body fat distribution. The study will be presented in August at the American Chemical Society national meeting in Boston.
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Study expected to boost research for hearing and balance therapies
09-25-2007 · EurekAlert!
Despite the compelling need for new treatments, hearing and balance research and development efforts have been hindered by the relative scarcity of inner ear hair cells. A new study by neuroscientists at the University of Virginia Health System promises to boost cell supplies and accelerate therapeutic advancements.
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Researchers Uncover Critical Player In Cell Communication
10-06-2006 · ScienceDaily
Johns Hopkins researchers have teased out the function of a protein implicated in Williams-Beuren syndrome, a rare cognitive disorder associated with overly social behavior and lack of spatial awareness. Called TFII-I, or TF "two eye," the protein long known to help control a cell's genes also controls how much calcium a cell takes in, a function critical for all cells, including nerves in the brain. The study will be published this week in Science.
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Neural stem cell study reveals mechanism that may play role in cancer
09-04-2007 · EurekAlert!
In the dynamic world of the developing brain, neural stem cells give rise to neurons deep within the brain’s fluid-filled ventricles. These newborn neurons then migrate along the stem cell fibers up to the neocortex, the seat of higher cognitive functions. Now, scientists have discovered a key mechanism of this migration -- one that may also play an important role in other developmental processes and diseases, including cancer.
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UF researchers test stem cell therapy for heart patients
10-04-2007 · EurekAlert!
University of Florida doctors treated the first patient in a new study to test whether a person's own stem cells can be used to restore blood flow to the heart by prompting new blood vessels to grow.
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New study finds blood-spinal cord barrier compromised in mice with ALS
11-20-2007 · EurekAlert!
The blood-spinal cord barrier is functionally impaired in areas of motor neuron damage in mice modeling amyotrophic lateral sclerosis, report researchers at the University of South Florida Center for Aging and Brain Repair. The barrier disruption was found in mice at both early and late stages of ALS, a progressive neurodegenerative disease affecting nerve cells in the brain and the spinal cord. The study appears in the online, open-access journal PLoS ONE.
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