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Key Regulator For Skin Stem Cells Identified
10-06-2006 · ScienceDailyBy turning on a single gene, researchers can prevent skin stem cells from maturing into the three types of adult skin cells -- epidermal, sebaceous and hair cells. They say this finding could have important implications for scientists trying to grow stem cells in the lab, for both research and potential therapies.
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Keywords: key, regulator, skin, stem, cells, identified, cell
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- Study identifies 5 genetic themes key to keeping stem cells in a primitive, flexible state
06-19-2007 · EurekAlert!
A team of Canadian scientists has identified 1,155 genes under the control of a gene called Oct4 considered to be the master regulator of the stem cell state. The study will be published in the June 20 edition of the online, open-access journal PLoS ONE.
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- Master regulatory gene of epithelial stem cells identified
05-03-2007 · EurekAlert!
The skin's ability to replace the tissue it sloughs off is controlled by a variety of genes. A new study from Harvard Medical School published in the May 4 issue of Cell, however, identifies a "master regulator" of this regeneration process not only for skin, but for many epithelial tissues including breast, prostate, and urogenital tract. This master regulator of epithelial stem cells turns out to be the p63 gene, a close relative to the well-known tumor-suppressing p53 gene.
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- Gene Key To Taste Bud Development Identified
10-02-2006 · ScienceDaily
Scientists have identified a gene that controls the development of taste buds. The gene, SOX2, stimulates stem cells on the surface of the embryonic tongue and in the back of the mouth to transform into taste buds, according to the researchers. Stem cells are immature cells that can develop into several different cell types depending on what biochemical instructions they receive.
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- Protein maintains cross talk between cells that control hair growth
02-14-2008 · EurekAlert!
Researchers at Rockefeller University have identified a signaling molecule that is critical for a type of skin cell, called dermal papilla, to ratchet up or clamp down the activity of genes that give them their molecular identity. Without these signals, these skin cells lose their hair-inducing properties -- findings that may provide a new understanding of how stem cells differentiate.
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- Forsyth scientists gain new understanding of adult stem cell regulation
08-01-2007 · EurekAlert!
Forsyth Institute scientists have discovered an important mechanism for controlling the behavior of adult stem cells. Research with the flatworm, planaria, found a novel role for the proteins involved in cell-to-cell communication. This work has the potential to help scientists understand the nature of the messages that control stem cell regulation -- such as the message that maintain and tells a stem cell to specialize and to become part of an organ (e.g., liver or skin).
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- When smell cells fail they call in stem cell reserves
04-29-2007 · EurekAlert!
Hopkins researchers have identified a backup supply of stem cells that can repair the most severe damage to the nerves responsible for our sense of smell. These reservists normally lie around and do nothing, but when neighboring cells die, the scientists say, the stem cells jump into action. A report on the discovery will appear online next week in Nature Neuroscience.
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- Study reveals how stem cells decide to become either skeletal or smooth muscle
10-10-2007 · EurekAlert!
Researchers have discovered that a key protein controls how stem cells 'choose' to become either skeletal muscle cells that move limbs, or smooth muscle cells that support blood vessels. The results suggest new ways to treat atherosclerosis and cancer, diseases that involve the creation of new blood vessels from stem cell reserves that would otherwise replace worn out skeletal muscle.
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- Team of scientists develops non-invasive method to track nerve-cell development in live human brain
11-08-2007 · EurekAlert!
A team of scientists including researchers at Cold Spring Harbor Laboratory have identified and validated the first biomarker that permits neural stem and progenitor cells to be tracked, non-invasively, in the brains of living human subjects. This important advance could lead to significantly better diagnosis and monitoring of brain tumors and a range of serious neurological and psychiatric disorders.
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- New cell type identified in cancer development
03-13-2007 · EurekAlert!
A team of scientists, led by Dr. Jian-Xin Gao, a researcher in the department of pathology at Ohio State University Medical Center, has identified a new set of cells he calls precancerous stem cells (pCSCs).
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- Neural stem cell study reveals mechanism that may play role in cancer
09-04-2007 · EurekAlert!
In the dynamic world of the developing brain, neural stem cells give rise to neurons deep within the brain’s fluid-filled ventricles. These newborn neurons then migrate along the stem cell fibers up to the neocortex, the seat of higher cognitive functions. Now, scientists have discovered a key mechanism of this migration -- one that may also play an important role in other developmental processes and diseases, including cancer.
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