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p53 gene mutations and inflammation trigger skin cancer

Squamous cell carcinoma (SCC) is a form of nonmelanoma skin cancer, which is the most common type of human malignancy with over 1 million new cases in the USA each year. In the July 2 issue of the Journal of Clinical Investigation, two separate studies by research teams at Glasgow University and Baylor College of Medicine uncover 2 previously unidentified regulators of SCC development, providing insights into the development of this potentially lethal disease.

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Keywords: p53, gene, mutations, inflammation, trigger, skin, cancer, mutation

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1. JCI Table of Contents -- July 2, 2007
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   This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, July 2, 2007, in the JCI, including: p53 gene mutations and inflammation trigger skin cancer; Neutrophils stand guard against tuberculosis infection; Mending a broken heart: Dysferlin repairs cardiac cell rupture; Calcium handling and cardiac arrhythmias: how the beat goes on; Hemoglobin production gets a helping hand; Recombinant Hemojuvelin protein: a treatment option for anemia; and others.
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   Israeli investigators have found that Ashkenazi Jewish women with ovarian cancer who have mutations in the BRCA1 or BRCA2 genes lived significantly longer than Ashkenazi Jewish ovarian cancer patients without these mutations. After up to nine years of follow-up, BRCA1/2 mutation carriers were 28 percent less likely to die from the disease, even though women with the BRCA mutations are significantly more likely to develop ovarian and breast cancers.
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8. Computer tool helps pinpoint risky gene mutations
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10. JCI table of contents: Nov. 1, 2007
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