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Gene therapy eradicates pancreatic cancer in preclinical trial
07-09-2007 · EurekAlert!A molecularly engineered therapy selectively embeds a gene in pancreatic cancer that shrinks or eradicates tumors, inhibits metastasis, and prolongs survival with virtually no toxicity, researchers from The University of Texas M. D. Anderson Cancer Center report in the July 9 edition of Cancer Cell.
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Keywords: gene, therapy, eradicates, pancreatic, cancer, preclinical, trial, eradicate
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- Henry Ford Hospital expands research on gene and radiation therapy for prostate cancer
02-06-2008 · EurekAlert!
Henry Ford Hospital is embarking on an expanded major clinical trial involving the use of gene therapy in combination with radiation therapy, to determine if the combined treatment is more effective than radiation therapy alone for patients with intermediate risk prostate cancer.The clinical trial is part of a $9 million grant from the National Cancer Institute awarded to Henry Ford to study the effectiveness of gene therapy to treat prostate cancer.
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- Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer
04-17-2007 · EurekAlert!
A cancer-suppressing gene has been successfully delivered into the tumors of stage four lung cancer patients via an intravenously administered lipid nanoparticle in a phase I clinical trial at the University of Texas M. D. Anderson Cancer Center. The gene, FUS1, also was found to be active in the metastatic nonsmall cell lung cancer tumors.
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- Tumor Suicide: Gene therapy makes cancer cells self-destruct
07-14-2007 · Science News Online
Microscopic bubbles of fat that deliver a suicide gene to tumor cells show success in treating pancreatic cancer in mice.
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- Dual gene therapy suppresses lung cancer in preclinical test
01-15-2007 · EurekAlert!
Combination gene therapy delivered in lipid-based nanoparticles drastically reduces the number and size of human non-small cell lung cancer tumors in mice, researchers at The University of Texas M. D. Anderson Cancer Center and the University of Texas Southwestern Medical Center report in the January 15 edition of Cancer Research.
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- Liverpool to trial new pancreatic cancer therapy
03-15-2007 · EurekAlert!
Patients in Liverpool are to trial a new therapy for pancreatic cancer -- a disease which sees most sufferers die within a year of diagnosis.
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- Gene therapy, cancer-killing viruses and new drugs highlight novel approaches to cancer treatment
04-17-2007 · EurekAlert!
Studies presented at the 2007 meeting of the American Association for Cancer Research show how researchers are using the new, as well as the natural, to help design and test new drugs to treat cancer.
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- Growth factor signals influence balance between normal growth and cancerous growth
11-09-2006 · EurekAlert!
Too much of a signaling protein called insulin-like growth factor-I (IGF-I) may fan the flames of cancer, while too little of the protein may cause short stature, dementia and osteoporosis. New research investigates how the growth hormone/IGF system is affected by the important tumor suppressor gene p53. This interplay of two signaling pathways reinforces questions about the long-term risks of prescribing growth hormone, while suggesting a future new avenue for cancer therapy.
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- First familial pancreatic cancer gene identified
12-11-2006 · EurekAlert!
At least 10 percent of pancreatic cancers are thought to be familial, i.e., caused by inherited genetic mutations. The responsible genes have so far remained elusive, but one of the research teams that had been on a pancreatic cancer gene hunt for years now reports success: Teri Brentnall (University of Washington), David Whitcomb (University of Pittsburgh), and colleagues publish the identification of the palladin gene as the one mutated in a large family they had been studying for a while.
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- Gene's activity points to more lethal subtype of AML
07-09-2007 · EurekAlert!
A new study shows that the activity of a particular gene can identify people who have a more lethal form of acute myeloid leukemia, singling out those patients who should receive more intense therapy. The gene, called ERG (for ETS-related gene), has also been linked to chronic leukemia and to breast and prostate cancer.
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- T vs. B: Re-engineered human T cells effectively target and kill cancerous B cells
09-18-2007 · EurekAlert!
Human white blood cells, engineered to recognize other malignant immune cells, could provide a novel therapy for patients with highly lethal B cell cancers such as acute lymphoblastic leukemia, according to researchers at Memorial Sloan-Kettering Cancer Center. By administering repeated doses of T cells designed to express an artificial receptor which recognizes human B cells, the researchers were able to eradicate cancer in 44 percent of mice bearing human ALL tumors.
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