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Mucins stand guard against gut infections

Mucins are large proteins that are secreted on the surface of the gut, and while long regarded as having a role as a barrier to mucosal infection, data to support this theory have been lacking. In a new JCI study researchers show that cell surface mucin 1 (Muc1) plays a critical role in protecting the mucosal lining of the gut from bacterial infection.

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Keywords: mucins, stand, guard, gut, infections, mucin, infection

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1. JCI table of contents: July 19, 2007
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   This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, July 19, 2007, in the JCI, including: "Mucins stand guard against gut infections"; "Despite different triggers of disease, all roads lead to lupus"; "ERK1/2 at root of congenital heart disease in Noonan syndrome"; "In insulin resistance, all fingers point to diminished levels of PKC-lambda"; "Keeping killer T cells under control in the liver"; and others.
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3. JCI Table of Contents -- July 2, 2007
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