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MicroRNA works with Ago2 protein to regulate blood cell development
07-26-2007 · EurekAlert!MicroRNAs became the stars of the RNA universe, when scientists found that these short RNAs can control whether or not genes are expressed. Provocative new findings cast new light on the genesis of these key biological regulators and how they carry out their function.
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Keywords: microrna, works, ago2, protein, regulate, blood, cell, development, work
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- MicroRNA 'sponges' could aid cancer studies
08-12-2007 · Massachusetts Institute of Technology (MIT)
MIT researchers have developed a new way to study the function of microRNA, the tiny strands of genetic material that help regulate a cell's genes. The work could shed light on microRNA's hypothesized role in tumor development.
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- Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
07-31-2007 · EurekAlert!
Working with human colorectal cancer cells, a University of Minnesota team, led by cancer biologists Zigang Dong and Ann Bode, has found the potential culprit among a network of enzymes that relay signals inside cells to regulate such functions as cell growth, cancer development and programmed cell death. The work suggests that drugs designed to disable the enzyme, known as TOPK, could have anticancer benefits. The study appears in the July issue of the journal Gastroenterology.
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- Penn researchers discover new molecular path to fight autoimmune diseases
03-06-2007 · EurekAlert!
Multiple sclerosis, diabetes, and arthritis are among a variety of autoimmune diseases that are aggravated when one type of white blood cell, called the immune regulatory cell, malfunctions. In humans, one cause of this malfunction is when a mutation in a gene called FOXP3 disables the immune cells’ ability to function. Penn researchers have discovered how to modify enzymes that act on the FOXP3 protein, in turn making the regulatory immune cells work better.
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- Penn researchers discover how microRNAs control protein synthesis
07-09-2007 · EurekAlert!
While most RNAs work to create, package and transfer proteins as determined by the cell's immediate needs, miniature pieces of RNA, called microRNAs (miRNAs) regulate gene expression. Recently, researchers from the University of Pennsylvania School of Medicine determined how miRNAs team up with a regulatory protein to halt protein production.
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- Discovery of an HIV inhibitor in human blood points to new drug class
04-19-2007 · EurekAlert!
A new study has pinpointed a natural ingredient of human blood that effectively blocks HIV-1, the virus predominantly responsible for human AIDS, from infecting immune cells and multiplying. The virus blocker might play a role in the progression of HIV to full-blown AIDS and -- because it works in a different way than existing antiretroviral inhibitors -- could lead to the development of another class of drugs in the fight against the pandemic disease.
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- Unique role for blood formation gene identified
09-12-2007 · EurekAlert!
All blood cell production in adults depends on the steady work of a vital gene that if lost results in early bone marrow failure, Dartmouth Medical School cancer geneticists have found. Their research reveals an unexpected role for the gene in sustaining the adult blood-forming system, and opens novel strategies for targeting the gene, which is often involved in a type of childhood leukemia.
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- Stress hormone may hasten the progression of certain blood cancers
11-19-2007 · EurekAlert!
Researchers here have shown that in cell cultures, the stress hormone norepinephrine appears to promote the biochemical signals that stimulate certain tumor cells to grow and spread. The finding, if verified, may suggest a way of slowing the progression and spread of some cancers enough so that conventional chemotherapeutic treatments would have a better chance to work.
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- JCI online early table of contents: Jan. 10 2008
01-10-2008 · EurekAlert!
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, Jan. 10, 2008, in the JCI, including: A new way to boost red blood cell numbers; A PIN(1) prick for lung scarring: inhibiting PIN1 reduces rodent lung scarring; The protein myocardin helps plug the ductus arteriosus; Understanding how carbon dioxide can impair lung function: and others.
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- Jefferson scientists find tumor suppressor gene protects against pre-cancerous development
11-01-2006 · EurekAlert!
Cell biologists have provided further evidence that a gene thought to play a role in suppressing tumors actually protects against the development of pre-cancerous cell growth as well. The researchers say that the gene, caveolin-1, which they found in two major types of breast cells, could be a potential target for future drugs aimed at preventing breast cancer. The work also suggests a potentially important role of the tumor "microenvironment" in the cancerous process.
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- Chemical switch triggers critical cell activities
01-16-2007 · EurekAlert!
The freeze-frame image of a molecular relay race, in which one enzyme passes off a protein like a baton to another enzyme, has solved a key mystery to how cells control some vital functions, according to investigators at St. Jude Children's Research Hospital. A report on this work appears in the January 14 advanced online publication issue of Nature.
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