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Lack of GBA2: A contraceptive for male mice

11-01-2006 · EurekAlert!

Although it had previously been thought that a protein known as GBA2 was important for bile acid metabolism, a new study appearing in the November issue of the Journal of Clinical Investigation shows that in mice GBA2 is in fact required for male fertility. This study might explain the contraceptive effect in mice of a treatment for humans lacking the related protein GBA1 and could lead to the development of a new male contraceptive.

Keywords: lack, gba2, contraceptive, male, mice

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JCI table of contents: Nov. 1, 2006
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This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, Nov. 1, 2006, in the JCI, including: Lack of GBA2: a contraceptive for male mice; Decreased TGF-beta signaling might make you demented; Gene therapy a possibility for metachromatic leukodystrophy?; Prostaglandins help plug a hole after birth; Why PSCK9 raises cholesterol levels; NF-kappa-B contributes to muscle wasting, and Lung DCs legitimate targets for treating asthma.
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