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Unknotting DNA clue to cancer syndrome

A new UC-Davis study that explains the actions of a gene mutation that causes early onset cancer provides a fundamental insight into the mechanism of DNA-break repair.

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Keywords: unknotting, dna, clue, cancer, syndrome

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1. Simple diagnostic test detects genetic signs of lung cancer in a patient's sputum
   01-18-2007 · EurekAlert!
   DNA coughed up along with phlegm could point to lung cancer, say researchers at the University of Maryland School of Medicine who are developing an inexpensive and non-invasive gene probe to help diagnose early stage lung cancer in current and former smokers.
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2. New study suggests Concord grape juice may provide protection against breast cancer
   08-09-2007 · EurekAlert!
   According to a new study, published in the current issue of the Journal of Medicinal Foods, natural compounds in Concord grape juice protected healthy human breast cells from DNA damage. Healthy human breast cells were exposed in a test tube to an environmental carcinogen, benzo(a)pyrene, that is able to initiate a chain of events leading to breast cancer. However, the introduction of Concord grape juice compounds blocked the connection of the carcinogen to the DNA of the healthy cells.
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3. Birth records hold pancreatic cancer clue
   08-15-2007 · EurekAlert!
   Pregnancies in Jerusalem in the 1960s and 1970s may hold vital clues about how pancreatic cancer and diabetes are linked. According to research published in the online open access journal BMC Medicine, women with a history of gestational diabetes had a higher risk of developing pancreatic cancer later in life.
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4. AVN944 inhibits IMPDH & induces apoptosis-related biomarkers in patients with hematologic cancers
   12-11-2006 · EurekAlert!
   IMPDH is highly upregulated in most hematological cancers and solid tumors -- an essential role in cancer cell synthesis of DNA and RNA. Inhibition of IMPDH represents a new and important approach to treat cancer. In a Phase I trial of AVN944, AvalonRx identified a set of 34 genes. These gene markers correlate with the biochemical effects of AVN944 on protein function -- believed to result in tumor cell apoptosis at the right doses.
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5. Taking Cancer's Fingerprint: Rapid genetic profiling for personalized therapy
   02-17-2007 · Science News Online
   A new, faster way to identify cancer-causing mutations in the DNA of tumor cells may pave the way for the next generation of custom-tailored cancer therapies.
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6. Chromium 6: A killer compound with an improbable trigger
   03-12-2007 · EurekAlert!
   Chromium 6, the cancer-causing compound that sparked the legal crusade by Erin Brockovich, can be toxic in tiny doses. Brown University scientists have uncovered the unlikely culprit: vitamin C. In new research, the Brown team shows that when vitamin C reacts with even low doses of chromium 6 inside human cells, it creates high levels of cancer-causing DNA damage and mutations.
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7. 2 heads are better than 1: 2 dysfunctional DNA repair pathways kill tumor cells
   04-12-2007 · EurekAlert!
   Individuals who inherit one mutant copy of any one of about 12 genes that make the proteins of the Fanconi Anemia pathway are at increased risk of developing cancer. This occurs when the remaining "good" copy of the gene becomes mutated in a specific cell type. However, hope of a new treatment for these cancers has now been provided by a new study indicating that inhibiting the protein ATM can kill these cancer cells.
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8. Mutant mouse provides insights into breast cancer
   12-08-2006 · EurekAlert!
   By discovering a mutant mouse that is highly susceptible to mammary tumors, Cornell researchers have found a novel potential link between genetic defects in DNA replication and breast cancer.
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9. Chromatin remodeling complex connected to DNA damage control
   08-09-2007 · EurekAlert!
   When molecular disaster strikes, causing structural damage to DNA, players in two important pathways talk to each other to help contain the wreckage, scientists at the University of Texas M. D. Anderson Cancer Center report in the August edition of Cell.
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10. First look at an enzyme target for antibacterial and cancer drugs
    12-20-2007 · EurekAlert!
    The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication, and is a prime target of antibacterial and anticancer drugs. Researchers with the US Department of Energy's Lawrence Berkeley National Laboratory and the University of California at Berkeleyhave produced the first three-dimensional structural images of a DNA-bound Type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division.
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