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Preclinical study links gene to brain aneurysm formation

08-07-2007 · EurekAlert!

University of Cincinnati neurovascular researchers have identified a gene that -- when suppressed or completely absent -- may predispose a person to brain aneurysms. Todd Abruzzo, MD, and his colleagues demonstrated that "knocking out" a gene known as endothelial nitric oxide synthase in an animal model led to intracranial aneurysm formation in 33 percent of study subjects. Scientists say this suggests that the gene may play an important role in the development of intracranial aneurysms.

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Keywords: preclinical, study, links, gene, brain, aneurysm, formation, link

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