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UCLA scientists produce functioning neurons from human embryonic stem cells

Scientists with the Institute of Stem Cell Biology and Medicine at UCLA were able to produce from human embryonic stem cells a highly pure, large quantity of functioning neurons that will allow them to create models of and study diseases such as Alzheimer's, Parkinson's, prefrontal dementia and schizophrenia.

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Keywords: ucla, scientists, produce, functioning, neurons, human, embryonic, stem, cells, scientist, neuron, cell

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1. Not all embryonic stem cell lines are created equal
   08-06-2007 · EurekAlert!
   When it comes to generating neurons, researchers have found that not all embryonic stem cell lines are equal. In comparing neurons generated from two NIH-approved embryonic stem cell lines, scientists have uncovered significant differences in the mature, functioning neurons generated from each line. The discovery implies that culture conditions during ES cell generation -- which have yet to be identified -- can influence the developmental properties of human ES cells.
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2. Scientists produce neurons from human skin
   02-22-2007 · EurekAlert!
   Scientists from Université Laval's Faculty of Medicine have succeeded in producing neurons in vitro using stem cells extracted from adult human skin. This is the first time such an advanced state of nerve cell differentiation has been achieved from human skin, according to lead researcher Professor François Berthod. This breakthrough could eventually lead to revolutionary advances in the treatment of neurodegenerative illnesses such as Parkinson's disease.
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3. Chemical cues turn embryonic stem cells into cerebellar neurons
   03-14-2007 · EurekAlert!
   Rockefeller University scientists show that embryonic stem cells implanted in the brain appear to develop into fully differentiated granule neurons, the most plentiful neuron in the cerebellum. The findings are a step toward understanding how embryonic stem cells could be regulated in vivo and ultimately used for cell replacement therapy, especially after childhood tumors, in the central nervous system.
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4. Simple recipe turns human skin cells into embryonic stem cell-like cells
   11-20-2007 · EurekAlert!
   A simple recipe -- including just four ingredients -- can transform adult human skin cells into cells that resemble embryonic stem cells, researchers report in an immediate early publication of the journal Cell, a publication of Cell Press. The converted cells have many of the physical, growth and genetic features typically found in embryonic stem cells and can differentiate to produce other tissue types, including neurons and heart tissue, according to the researchers.
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5. UCLA stem cell scientists reprogram human skin cells into embryonic stem cells
   02-11-2008 · EurekAlert!
   UCLA stem cell scientists have reprogrammed human skin cells into cells with the same unlimited properties as embryonic stem cells without using embryos or eggs.
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6. Human embryonic stem cells remain embryonic because of epigenetic factors
   10-04-2007 · EurekAlert!
   A human embryonic stem cell is reined in -- prevented from giving up its unique characteristics of self-renewal and pluripotency -- by the presence of a protein modification that stifles genes that would prematurely instruct the cell to develop into specialized tissue. Thanks to the simultaneous presence of different protein modifications, stem cells are primed and poised, ready to develop into specialized body tissue, Singapore scientists reported.
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7. Scientists identify a mouse embryonic stem cell more like our own
   06-27-2007 · EurekAlert!
   Scientists have discovered a new type of mouse embryonic stem cell that is the closest counterpart yet to human embryonic stem cells, the National Institutes of Health announced today. The cells are expected to serve as an improved model for human ES cells in studies of regeneration, disease pathology and basic stem cell biology.
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8. Human embryonic stem cell lines created that avoid immune rejection
   12-20-2007 · EurekAlert!
   In a groundbreaking experiment published in Cloning & Stem Cells, scientists from International Stem Cell Corp. derived four unique embryonic stem cell lines that open the door for the creation of therapeutic cells that will not provoke an immune reaction in large segments of the population. The stem cell lines are "HLA-homozygous," meaning that they have a simple genetic profile in the critical areas of the DNA that code for immune rejection.
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9. Reversing cancer cells to normal cells
   04-29-2007 · EurekAlert!
   A Northwestern University scientist describes new research that used an innovative experimental approach to provide unique insights into how scientists can change human metastatic melanoma cells back to normal-like skin cells -- by exposing the tumor cells to the embryonic microenvironment of human embryonic stem cells, the zebra fish and the chick embryo.
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10. Human embryonic stem cells derived from preimplantation genetically diagnosed embryos
    11-14-2007 · EurekAlert!
    A human stem cell line derived from embryos that were identified by preimplantation genetic diagnosis to carry the mutation for fragile X syndrome has provided an unprecedented view of early events associated with this disease. In addition to giving scientists fresh insight into fragile X, results from this unique model system have emphasized the value of this new source of embryonic stem cells and may have a significant impact on the way that genetic diseases are studied in the future.
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