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Reactivating a critical gene lost in kidney cancer reduces tumor growth
08-15-2007 · EurekAlert!Researchers at Mayo Clinic Jacksonville, have found that a key gene is often "silenced" in clear cell renal cell carcinoma, the most common type of kidney cancer, and when they restored that gene in human kidney cancer cells in culture and animal experiments, tumors stopped growing and many disappeared.
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Keywords: reactivating, critical, gene, lost, kidney, cancer, tumor, growth
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- Growth factor signals influence balance between normal growth and cancerous growth
11-09-2006 · EurekAlert!
Too much of a signaling protein called insulin-like growth factor-I (IGF-I) may fan the flames of cancer, while too little of the protein may cause short stature, dementia and osteoporosis. New research investigates how the growth hormone/IGF system is affected by the important tumor suppressor gene p53. This interplay of two signaling pathways reinforces questions about the long-term risks of prescribing growth hormone, while suggesting a future new avenue for cancer therapy.
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- Discovery of widespread tumor growth gene holds promise for effective anti-cancer treatment
09-23-2007 · EurekAlert!
Italian scientists will announce on Monday (Sept. 24) that they have found a new and promising target for anti-tumor therapy in cancer. Professor Saverio Alberti, from the CESI, University of Chieti Foundation, Chieti, will tell the European Cancer Conference that he and his team have found a widespread mechanism for the stimulation of tumor growth in man, and that this is leading to the development of novel diagnostic and therapeutic procedures.
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- Study shows blood markers can help choose best dose for antiangiogenic drugs
10-25-2007 · EurekAlert!
Scientists at Sunnybrook have new information that may help to improve the use of anti-cancer drugs designed to block the growth of new blood vessels in tumors, a process called angiogenesis that is critical to tumor growth. While these antiangiogenic drugs are effective, at present there are no reliable methods for determining whether they are working, if the right dose is used, or if a patient will benefit from treatment.
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- Gene variation may elevate risk of liver tumor in patients with cirrhosis
01-01-2008 · EurekAlert!
A particular gene variation appears to significantly increase the risk that individuals with cirrhosis of the liver will go on to develop hepatocellular carcinoma, a liver tumor that is the third leading cause of cancer death. Researchers from Massachusetts General Hospital Cancer Center and colleagues in France have found that a single alteration in the epidermal growth factor gene may greatly increase the risk that cirrhotic patients will develop the tumor.
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- There goes the neighborhood: Vascular niche nurtures brain tumor stem cells
01-16-2007 · EurekAlert!
New research published in the January 2007 issue of the journal Cancer Cell, published by Cell Press, reveals that small blood vessels associated with brain tumors orchestrate a distinct microenvironment that is critical for maintaining cancer stem cells (CSCs). Importantly, antiangiogenic drugs that disrupt this microenvironment reduce the CSC population and arrest tumor growth.
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- Notorious cancer gene may work by destroying messenger
03-19-2007 · EurekAlert!
A new study suggests how a notorious cancer gene may contribute to tumor growth. The insight emerged from a long-running study of a protein called PMR1, the key player in an unusual mechanism that cells use to quickly stop production of certain important proteins.
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- Defects in critical gene lead to accelerated lung tumor growth
08-05-2007 · EurekAlert!
Scientists at the University of North Carolina at Chapel Hill School of Medicine and Harvard Medical School have found that a mutated tumor suppressor gene, LKB1, may result in lung tumors that are more aggressive and more likely to spread throughout the body.
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- Tumor-suppressor gene is critical for placenta development
01-09-2007 · EurekAlert!
An important cancer-related gene may play a critical role in the development of the placenta, the organ that controls nutrient and oxygen exchange between a mother and her fetus during pregnancy, and perhaps in miscarriages. Those conclusions come from a new study of the retinoblastoma (Rb) gene in mice. In humans, this gene, when mutated, raises the risk of a rare cancer of the eye called retinoblastoma.
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- 'Gateway' gene discovered for brain cancer
02-14-2007 · EurekAlert!
Researchers have discovered that the same genetic regulator that triggers growth of stem cells during brain development also plays a central role in the development of the lethal brain cancer malignant glioma. In experiments on mice with such gliomas, they showed that knocking out the function of a particular regulatory protein, Olig2, almost completely eliminated tumor formation.
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- Researchers specifically manipulate tumor angiogenesis gene
10-13-2007 · EurekAlert!
Vascular endothelial growth factor is secreted by most tumors and has been shown to play an important role in tumor angiogenesis. RNAi is the sequence-specific, posttranscriptional gene silencing method initiated by double-stranded RNAs. We planned to find a better VEGF specific RNAi for colon cancer.
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