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Low levels of key protein may indicate pancreatic cancer risk
08-15-2007 · EurekAlert!A protein that dwindles in response to obesity and a sedentary lifestyle may one day help doctors predict which people are at increased risk for pancreatic cancer, new research by Dana-Farber Cancer Institute and collaborating scientists indicates.
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- Protein may be linked to melanoma recurrence
06-02-2007 · EurekAlert!
Higher levels of a protein called S-100 in melanoma patients may correlate with a higher risk of the disease returning, say researchers at the University of Pittsburgh Cancer Institute. The study tested serum samples from 103 patients treated with high-dose interferon an average of eight years prior. When the researchers examined levels of S-100 in the samples, they found that the higher the level of the protein, the greater likelihood the disease had returned.
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- PSA doubling predicts prostate cancer recurrence
04-09-2007 · EurekAlert!
A detectable level of prostate-specific antigen (PSA) is the first indicator of recurrent prostate cancer after radical prostatectomy. In a new Mayo Clinic study, the concept of PSA doubling time is found to be a reliable tool to distinguish which patients have prolonged innocuous PSA levels after therapy from those who are at great risk for disease recurrence and death from prostate cancer. Doubling time is defined as the duration for PSA levels in the blood to increase by 100 percent.
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- Other highlights in the February 21 JNCI
02-20-2007 · EurekAlert!
Also in the February 21 JNCI are a new screening method for those at risk for a hereditary colorectal cancer, a mouse study of low-dose bisphosphonates' antitumor effects, and research on a protein that is active in metastasis suppression.
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- Sex, sugar and metabolic disease
11-08-2007 · EurekAlert!
Overweight children and adults have low blood levels of the protein SHGB, which transports sex steroids and regulates their tissue entry. Low levels of SHGB are a marker of the metabolic syndrome, a medical disorder that increases an individual's risk of developing type 2 diabetes and heart disease. New research in mice and in vitro using human cells provides an explanation as to why low SHGB levels are a good marker of the metabolic syndrome.
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- Enzyme may hold key to new treatment of diabetic kidney disease
11-07-2006 · EurekAlert!
Northwestern University researchers have found an enzyme, called "ACE2," may hold the potential to treat diabetic kidney disease, the most common form of kidney disease.The researchers have found low levels of the ACE2 enzyme in kidneys of diabetic mice. When ACE2 was further decreased with an inhibitor drug, kidney disease worsened. Studies are now needed using compounds that increase the level of ACE2 in the kidneys of diabetic mice to see if it reverses or prevents kidney disease.
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- Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
10-11-2007 · EurekAlert!
A tumor-blocking protein previously implicated in prostate and breast cancer development may also be behind the most aggressive type of pancreatic cancer. Researchers have discovered that the protein pp32 -- which normally applies the brakes on a cancer-causing gene -- is missing in an aggressive form of pancreatic cancer. Though the work is preliminary, the scientists say, the absent protein could eventually become a marker for the disease and a potential drug target.
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- Low level of neuronal receptor linked to mild cognitive impairment and Alzheimer's disease
09-04-2007 · EurekAlert!
Results of a new study indicate a strong link between the loss of the neuronal receptor LR11and onset of mild cognitive impairment (MCI), often a harbinger of Alzheimer's disease. The findings also show that levels of LR11 in the brain tissue reflect the severity of cognitive impairment and may predict which individuals will progress to Alzheimer's disease.
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- Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
08-10-2007 · EurekAlert!
Concentrated chemicals derived from green tea dramatically boosted production of a group of key detoxification enzymes in people with low levels of these beneficial proteins, according to researchers at Arizona Cancer Center.
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- Short-term studies suggest that whole grain oats may reduce risk factors for coronary heart disease
04-17-2007 · EurekAlert!
Trials lasting four to eight weeks indicate that including whole grain oats in your diet may lower total and low-density lipoprotein cholesterol. Coronary heart disease (CHD) is a major cause of death and ill health. One of the risk factors for CHD is elevated blood levels of total cholesterol and of low density lipoprotein cholesterol. Existing observational studies indicate that wholegrain cereals may reduce the risk of CHD, possibly by reducing cholesterol levels.
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- Lack of a protein in lung tumors may increase risk of death
03-26-2007 · EurekAlert!
A study of human lung tumors indicates that lung cancer patients who lack a particular protein may do more poorly than those with normal levels of that same protein. If the findings are verified in a clinical trial, the absence of the protein might be used to identify lung cancer patients who need more aggressive therapy after surgery.
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