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Tumors use enzyme to recruit regulatory T-cells and suppress immune response
08-16-2007 · EurekAlert!One way tumors fly under the radar of the immune system is by using IDO, an enzyme used by fetuses to help avoid rejection, to recruit powerful regulatory T cells that turn down the immune response, researchers say.
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Keywords: tumors, enzyme, recruit, regulatory, t-cells, suppress, immune, response, tumor, cells
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- 'Super' enzyme may lead way to better tumor vaccines
12-03-2006 · EurekAlert!
A "super" form of the enzyme Akt1 could provide the key to boosting the effect of tumor vaccines by extending the lives of dendritic cells, the immune-system master switches that promote the response of T-cells, which attack tumors.
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- Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread
01-10-2008 · EurekAlert!
A protein that helps prevent a woman's body from rejecting a fetus may also play an important role in enabling pancreatic cancer cells to evade detection by the immune system, allowing them to spread in the body. Researchers found that the metastatic pancreatic cancer cells in the lymph nodes produce enough of the protein, IDO, to wall-off the immune system's T-cells and recruit cells that suppress the immune response to the tumor.
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- A friendly foe -- Bacteria residing in the gut boost immune response to tumors
07-26-2007 · EurekAlert!
Total body irradiation (TBI), which depletes the body of lymphocytes, improves the ability of tumor-specific T cells to cause tumor regression. In a new JCI study researchers show that, in mice, lymphodepletion does not fully account for the tumor regression observed following TBI. They show that disruption of the population of bacteria that normally reside in the gut without causing disease also plays a role in the effectiveness of this therapeutic approach against cancer.
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- Blood-vessel blocker aids cancer-killing virus
11-27-2007 · EurekAlert!
Cancer-killing viruses are a promising therapy for incurable brain tumors, but their effectiveness has been limited in part because immune cells rapidly eliminate them. That immune response might be slowed, and the virus given more time to kill cancer cells, by blocking the growth of blood vessels in the tumor, new Ohio State research suggests. The study indicates that pretreatment with a drug that blocks blood-vessel growth might improve the effectiveness of cancer-killing viruses.
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- Second pathway behind HIV-associated immune system dysfunction identified
09-30-2007 · EurekAlert!
Researchers at the Partners AIDS Research Center at Massachusetts General Hospital may have discovered a second molecular 'switch' that turns off the immune system's response against HIV. Last year the same team identified a molecule that suppresses the activity of HIV-specific CD8 T cells that should destroy virus-infected cells. Now they describe how a regulatory protein called CTLA-4 inhibits the action of HIV-specific CD4 T cells that control the overall response against the virus.
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- Brain tumors coax important support from nearby immune system cells
04-11-2007 · EurekAlert!
Developing brain tumors can coax assistance from nearby cells known as microglia, according to a new study from scientists at Washington University School of Medicine in St. Louis. The researchers have identified one protein made by microglia that helps accelerate tumor growth and are looking for others.
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- Chemotherapy may enhance the effectiveness of brain tumor vaccines
06-03-2007 · EurekAlert!
Chemotherapy temporarily hinders the body's immune response, creating a concern that it may interfere with the promising new cancer vaccines being used against brain tumors. But a new study led by researchers at the Preston Robert Tisch Brain Tumor Center at Duke University and The University of Texas M. D. Anderson Cancer Center has found that the opposite is true: chemotherapy may actually enhance the effectiveness of the vaccines.
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- JCI table of contents: June 7, 2007
06-07-2007 · EurekAlert!
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online June 7, 2007, in the JCI, including: "Combination therapy reduces tumor resistance to radiation"; "Improved prediction of prostate cancer recurrence"; "Role of GM-CSF in the immune response to tumors"; "Protein C signaling impacts inflammatory bowel disease"; "Iron imbalance in anemia: Hints from HIF"; and "Phosphorylation state of eNOS is key to blood vessel function."
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- Immune response to cancer stem cells may dictate cancer's course
03-26-2007 · EurekAlert!
Mounting evidence shows that a tumor's growth and spread may depend on "cancer stem cells," which comprise only a very small subset of the tumor. A new study by Rockefeller University scientists shows that immunity to cancer stem cells may help protect people with a precancerous condition from developing the full-blown disease, and that these cells could be an important target for cancer vaccines.
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- Holographic images use shimmer to show cellular response to anticancer drug
03-06-2007 · EurekAlert!
The response of tumors to anticancer drugs has been observed in real-time 3-D images using technology developed at Purdue University. The new digital holographic imaging system uses a laser and the same microchip used in household digital cameras, to see inside tumor cells. The device also may have applications in drug development and medical imaging.
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