Daily non-political popular news in brief.

Study examines the mechanisms that silence the estrogen receptor gene alpha during breast cancer

The mechanisms that silence the estrogen receptor gene alpha (ER-α) in certain breast cancer cell lines may be closer to being unlocked, according to a study by researchers at Temple University's Sbarro Institute for Cancer Research and Molecular Medicine.

Read more »

Keywords: study, examines, mechanisms, silence, estrogen, receptor, gene, alpha, breast, cancer, examine, mechanism

« Previous | Next »

Similar news on "Study examines the mechanisms that silence the estrogen receptor gene alpha during breast cancer":

1. Src inhibitors may prove beneficial in breast cancer therapy
   07-12-2007 · EurekAlert!
   Estrogen, which binds estrogen receptor alpha (ER-alpha), is a risk factor for breast cancer development. However, one-third of new breast cancers lack detectable ER-alpha. These ER-alpha-negative cancers are more aggressive and have a worse prognosis than do ER-alpha-positive breast cancers, and have been thought to be estrogen independent. In a new JCI study, University of Miami researchers shed further light on the mechanisms regulating ER-alpha expression levels during breast cancer.
   Similar news · Read more »
   
2. A new computational technique predicts side-effects of a major cancer drug
   11-27-2007 · EurekAlert!
   Researchers at the University of California San Diego have developed a novel computer technique to search for the side effects of major pharmaceuticals. The study, reported Nov. 30 in PLoS Computational Biology, relates to a class of drugs known as Select Estrogen Receptor Modulators, which includes tamoxifen, the most prescribed drug in the treatment of breast cancer.
   Similar news · Read more »
   
3. Recent declines in breast cancer mortality greatest in women under 70
   04-02-2007 · EurekAlert!
   A new study shows that recent declines in breast cancer mortality rates have been most significant among women with estrogen receptor (ER)-positive tumors and women younger than 70. The results of the study are being published online April 2 in the Journal of Clinical Oncology.
   Similar news · Read more »
   
4. New 'knock-out' gene model provides molecular clues to breast cancer
   09-05-2007 · EurekAlert!
   New insights into the role of estrogen receptor in mammary gland development may help scientists better understand the molecular origin of breast cancer, according to new research from the University of Cincinnati.
   Similar news · Read more »
   
5. Unique estrogen receptor linked to metastatic breast cancer
   11-01-2006 · EurekAlert!
   Breast cancer awareness month may have passed, but researchers remain focused on the disease with a new study showing that a unique estrogen receptor found in breast cancer tumors is a predictor of tumor size and metastases. The study, led by researchers at Rhode Island Hospital and Brown Medical School, is published in the Nov. 1 issue of Clinical Cancer Research.
   Similar news · Read more »
   
6. Newly identified mechanism for silencing genes points to possible anti-cancer strategies
   05-16-2007 · EurekAlert!
   Scientists are only beginning to appreciate the extraordinary degree of control exercised over every step of the gene-to-protein production process. Only about 10 percent of human genes, for example, are active in a given cell at a given time, with the remaining 90 percent silenced by a various mechanisms. In a just-published study in Nature, scientists report an important new gene-silencing mechanism that points to promising potential targets for anti-cancer interventions.
   Similar news · Read more »
   
7. Extracts of catfish caught in polluted waters cause breast cancer cells to multiply
   11-07-2007 · EurekAlert!
   Exposing estrogen-sensitive breast cancer cells to extracts of fish caught in areas with heavy sewer and industrial waste causes the cells to multiply, according to a University of Pittsburgh study. The study, which tested extracts from fish caught in the Allegheny and Monongahela rivers near Pittsburgh, suggests that fish contain substances that mimic the actions of estrogen, the female hormone, and that chemicals that mimic estrogen may be making their way into the region's waterways.
   Similar news · Read more »
   
8. Breast cancer risk varies among women who are carriers of BRCA1 and BRCA2 gene mutations
   01-08-2008 · EurekAlert!
   Breast cancer risk varies widely among women who are carriers of the BRCA1 and BRCA2 mutations, according to a new study published in the Jan. 9, 2008, issue of the Journal of the American Medical Association.
   Similar news · Read more »
   
9. Moving beyond tamoxifen: Drug discovery and the future of selective hormone receptor modulators
   02-15-2008 · EurekAlert!
   How did a failed contraceptive become the first targeted therapy for the treatment of breast cancer? The transformation of tamoxifen, from cast-off to lifesaver, laid the foundation for a new class of therapeutics -- selective estrogen receptor modulators. V. Craig Jordan, a researcher at the Fox Chase Cancer Center in Philadelphia, Jordan reports on efforts to use the lessons from tamoxifen to develop new hormone receptor-related drugs for both women and men.
   Similar news · Read more »
   
10. New link between estrogen and breast cancer
    08-24-2007 · EurekAlert!
    The female sex hormone estrogen turns on a gene linked to breast cancer, according to new research by Brisbane scientists.
    Similar news · Read more »