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Gene triggers obsessive compulsive disorder-like syndrome in mice
08-22-2007 · EurekAlert!Using genetic engineering, researchers have created an obsessive-compulsive disorder-like set of behaviors in mice and reversed them with antidepressants and genetic targeting of a key brain circuit. The study, by National Institutes of Health-funded researchers, suggests new strategies for treating the disorder.
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Keywords: gene, triggers, obsessive, compulsive, disorder-like, syndrome, mice, trigger, disorder, like
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BDNF has been a subject of keen interest, turning up in studies of conditions ranging from central hypoventilation syndrome to obsessive-compulsive disorder, depression, bipolar disorder and schizophrenia -- a range of disorders uncannily parallel to those produced by mutations in the "Rett gene," MeCP2. In 2003, two groups found that MeCP2 regulates BDNF transcription. New studies have begun to shed light on the interplay of MeCP2 and BDNF.
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- Groomed for Trouble: Mice yield obsessive-compulsive insights
08-25-2007 · Science News Online
Mice lacking a gene that makes a certain brain protein display behaviors much like those of people with obsessive-compulsive disorder, a poorly understood psychiatric ailment.
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- Fragile X retardation syndrome corrected in mice
12-19-2007 · EurekAlert!
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- Researchers identify proteins involved in new neurodegenerative syndrome
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The interplay of two proteins that bind to messenger RNA, a molecule that mediates translation of the information encoded in genes into proteins, triggers the appearance of fragile X-associated tremor/ataxia syndrome, a late-life disorder associated with the gene that causes fragile X syndrome in children, said researchers from Baylor College of Medicine in Houston and Emory University School of Medicine in a report that appears today in the journal Neuron.
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- Mice provide important clues to obsessive-compulsive disorder
08-22-2007 · EurekAlert!
Mice born without a key brain protein compulsively groom their faces until they bleed and are afraid to venture out of the corner of their cages. When given a replacement dose of the protein in a specific region of the brain, or the drugs used to treat humans suffering from obsessive-compulsive disorder, many of these mice seem to get better.
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- Fragile X syndrome -- A stimulating environment restores neuronal function in mice
05-23-2007 · EurekAlert!
A new study of the malfunctioning neuronal machinery of Fragile X syndrome reveals that it can be restored by a stimulating environment. The study found that mice genetically altered to have the same defect as humans with the disorder benefited from an environment with constantly changing toys and access to "play cages." Fragile X syndrome is the most common form of inherited mental retardation, occurring in 1 in 3600 males and 1 in 4000 to 6000 females.
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- Rapid effects of intensive therapy seen in brains of patients with OCD
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In a study that may significantly advance the understanding of how cognitive-behavioral therapy affects the brain, researchers have shown that significant changes in activity in certain regions of the brain can be produced with as little as four weeks of daily therapy in patients with obsessive-compulsive disorder. The discovery could have important clinical implications, according to principal investigator Sanjaya Saxena, M.D., director of the obsessive-compulsive disorders program at the UCSD School of Medicine.
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02-08-2007 · EurekAlert!
Researchers at Vanderbilt University Medical Center and Erasmus Medical Center show that preventing the inhibition of CaMKII reverses the neurological deficits in a mouse model of Angelman syndrome, a rare disorder that causes mental retardation, motor impairments and seizures.
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