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New link between estrogen and breast cancer

08-24-2007 · EurekAlert!

The female sex hormone estrogen turns on a gene linked to breast cancer, according to new research by Brisbane scientists.

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Keywords: link, estrogen, breast, cancer

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    07-12-2007 · EurekAlert!
    Estrogen, which binds estrogen receptor alpha (ER-alpha), is a risk factor for breast cancer development. However, one-third of new breast cancers lack detectable ER-alpha. These ER-alpha-negative cancers are more aggressive and have a worse prognosis than do ER-alpha-positive breast cancers, and have been thought to be estrogen independent. In a new JCI study, University of Miami researchers shed further light on the mechanisms regulating ER-alpha expression levels during breast cancer.
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    Women with higher levels of physical activity may have a reduced risk of breast cancer after menopause, according to a report in the December 11/25 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. The association appears to be stronger for estrogen receptor positive/progesterone receptor negative tumors (which are typically more aggressive) than for other types of breast cancer tumors.
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    04-17-2007 · EurekAlert!
    A study from the University of Pittsburgh School of Medicine suggests that fish caught in Pittsburgh rivers show evidence of estrogen-like activity, indicating that chemicals that mimic the female hormone may be making their way into the region's waterways. The study, being presented at the annual meeting of the American Association for Cancer Research, also found that when the researchers treated breast cancer cells in culture with fish extracts, the cells grew at increased rates.
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