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Groomed for Trouble: Mice yield obsessive-compulsive insights
08-25-2007 · Science News OnlineMice lacking a gene that makes a certain brain protein display behaviors much like those of people with obsessive-compulsive disorder, a poorly understood psychiatric ailment.
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Keywords: groomed, trouble, mice, yield, obsessive-compulsive, insights, obsessive, compulsive, insight
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BDNF has been a subject of keen interest, turning up in studies of conditions ranging from central hypoventilation syndrome to obsessive-compulsive disorder, depression, bipolar disorder and schizophrenia -- a range of disorders uncannily parallel to those produced by mutations in the "Rett gene," MeCP2. In 2003, two groups found that MeCP2 regulates BDNF transcription. New studies have begun to shed light on the interplay of MeCP2 and BDNF.
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In a study that may significantly advance the understanding of how cognitive-behavioral therapy affects the brain, researchers have shown that significant changes in activity in certain regions of the brain can be produced with as little as four weeks of daily therapy in patients with obsessive-compulsive disorder. The discovery could have important clinical implications, according to principal investigator Sanjaya Saxena, M.D., director of the obsessive-compulsive disorders program at the UCSD School of Medicine.
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