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New 'knock-out' gene model provides molecular clues to breast cancer
09-05-2007 · EurekAlert!New insights into the role of estrogen receptor in mammary gland development may help scientists better understand the molecular origin of breast cancer, according to new research from the University of Cincinnati.
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- New pathway provides more clues about BRCA1 role in breast cancer
01-15-2008 · EurekAlert!
A breast cancer gene's newly discovered role in repairing damaged DNA may help explain why women who inherit a mutated copy of the gene are at increased risk for developing both breast and ovarian cancer.
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- Researchers identify unusual molecular switch for common form of advanced breast cancer
11-08-2007 · EurekAlert!
New evidence demonstrates that a novel molecular switch is involved in the development of a common form of advanced breast cancer, known as locally advanced breast cancer. The research, published by Cell Press in the Nov. 9, 2007 issue of Molecular Cell, provides an exciting paradigm shift in the understanding of a key event in breast cancer development and presents new therapeutic opportunities for this deadly disease.
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- Unknotting DNA clue to cancer syndrome
08-02-2007 · EurekAlert!
A new UC-Davis study that explains the actions of a gene mutation that causes early onset cancer provides a fundamental insight into the mechanism of DNA-break repair.
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- Biomarkers predict risk for invasive breast cancer years before the tumor develops
11-12-2007 · EurekAlert!
A team of scientists from the University of California San Francisco has identified distinct molecular markers that predict whether or not a woman is likely to develop subsequent invasive cancer after initial diagnosis with a noninvasive form of early breast cancer. The research, published by Cell Press in the November issue of Cancer Cell, provides critical information that can be used to determine whether a woman should receive more or less aggressive therapy.
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- Enhanced DNA-repair mechanism can cause breast cancer
10-15-2007 · EurekAlert!
Although defects in the "breast cancer gene," BRCA1, have long been known to increase the risk for breast cancer, exactly how the defects lead to tumor growth has remained a mystery. Now scientists provide insight into how the normal BRCA1 gene suppresses the growth of tumors as well as the nature of the genetic instability that leads to cancer when BRCA1 is defective.
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11-13-2007 · EurekAlert!
Other highlights in the Nov. 13 JNCI include a simple model to predict breast cancer risk, the link between smoking and rectal cancer, research into how a cancer drug causes heart damage, a gene that may inhibit lung cancer, BRCA1's influence on drug response, and the difficulties assigning patients to cancer subtypes.
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New understanding of a protein that spurs the growth of pancreatic cancer could lead to a new vaccine against the deadly disease, said researchers at Baylor College of Medicine in Houston in a report appearing in the current edition of the journal Molecular Cancer Therapeutics.
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06-03-2007 · EurekAlert!
When women under 50 develop breast cancer the disease tends to be more aggressive and less responsive to treatment than when it occurs in older women. Researchers at the Duke Institute for Genome Sciences & Policy and the Duke University Comprehensive Cancer Center may have discovered a part of the reason why, and their findings may lead to targeted therapies that can help treat patients more effectively.
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- Modeling lung cancer
02-12-2007 · EurekAlert!
In a new report in the February 15 issue of G&D, Dr. Martin McMahon and colleagues present a novel mouse model of non-small cell lung cancer, which will serve as a useful tool to test the efficacy of novel chemotherapeutic drug therapies in the early stages of lung tumorigenesis. Their paper provides evidence to support the use of a relatively new class of drugs, called MEK inhibitors, for lung cancer patients whose tumors contain mutations in the BRaf gene.
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