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Putting stem cell research on the fast track

Engineers at Rensselaer Polytechnic Institute have developed tools to help solve two of the main problems slowing the progress of stem cell research -- how to quickly test stem cell response to different drugs or genes, and how to create a large supply of healthy, viable stem cells to study from only a few available cells.

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1. UCI launches effort to develop patient-specific stem cell lines
   05-14-2007 · EurekAlert!
   UC Irvine neurobiologist Hans Keirstead and his research team today launched a project to develop stem cell lines that genetically match human patients. These lines would allow scientists to better study conditions ranging from diabetes to Parkinson's disease, and they would provide the basis for potential patient-specific stem cell treatments.
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2. Loss of stem cells correlates with premature aging in animal study
   06-06-2007 · EurekAlert!
   Researchers at the Abramson Family Cancer Research Institute of the University of Pennsylvania have found that deleting a gene important in embryo development leads to premature aging and loss of stem cell reservoirs in adult mice. This gene, ATR, is essential for the body's response to damaged DNA, and mutations in proteins in the DNA damage response underlie certain types of cancer and other disorders in humans.
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3. Forsyth scientists gain new understanding of adult stem cell regulation
   08-01-2007 · EurekAlert!
   Forsyth Institute scientists have discovered an important mechanism for controlling the behavior of adult stem cells. Research with the flatworm, planaria, found a novel role for the proteins involved in cell-to-cell communication. This work has the potential to help scientists understand the nature of the messages that control stem cell regulation -- such as the message that maintain and tells a stem cell to specialize and to become part of an organ (e.g., liver or skin).
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4. Team of scientists develops non-invasive method to track nerve-cell development in live human brain
   11-08-2007 · EurekAlert!
   A team of scientists including researchers at Cold Spring Harbor Laboratory have identified and validated the first biomarker that permits neural stem and progenitor cells to be tracked, non-invasively, in the brains of living human subjects. This important advance could lead to significantly better diagnosis and monitoring of brain tumors and a range of serious neurological and psychiatric disorders.
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5. OHSU Cancer Institute research discovery opens new window to understanding chronic myeloid leukemia
   12-09-2007 · EurekAlert!
   Oregon Health & Science University Cancer Institute researchers have opened a new window into the roots of chronic myeloid leukemia (CML). "We are looking under the surface of CML to understand better where the cancer is coming from. We have discovered abnormal cells in the early stem cell population in some CML patients, which don't belong to the CML clone. These are abnormal cells that are not part of the CML clone," said Thomas Bumm, M.D., OHSU Cancer Institute member.
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6. Cancer stem cell marker also drives transcription in normal cells
   01-17-2008 · EurekAlert!
   New research links the recently discovered function of a multi-faceted transcriptional complex to control of gene expression in both normal cells and cancer stem cells...
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7. Mass. General researchers identify master cardiac stem cell
   11-22-2006 · EurekAlert!
   Researchers from the Massachusetts General Hospital Cardiovascular Research Center have discovered what appears to be a master cardiac stem cell, capable of differentiating into the three major cell types of the mammalian heart. In a report to appear in the journal Cell, receiving early online release, they describe identifying these progenitor cells in mice, cloning them from embryonic stem cells, and showing that cloned cells can differentiate into cardiac muscle, smooth muscle or endothelial cells.
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8. Soft-cell approach cuts animal tests
   02-06-2007 · EurekAlert!
   A new way to test the safety of the air we breathe is proving faster, cheaper and more humane than exposing laboratory animals to airborne chemical hazards, say UNSW scientists. Researchers at the university's Chemical Safety and Applied Toxicology Laboratories have developed an animal-free alternative that exposes living human cells to air pollutants inside a small chamber. The breakthrough could fast-track scientific understanding of the threat to human health posed by thousands of airborne chemical compounds.
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9. Dartmouth professor makes case for ethically universal stem cell lines
   06-07-2007 · EurekAlert!
   A recent paper in Nature Review Genetics considers six current approaches to deriving human embryonic stem cell (hESC) lines. "I think we can pursue hESC research and also respect the sensitivities of our fellow citizens. It's not impossible to do both," says the researcher.
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10. 18-year-old Singaporean student to present stem cell research paper at conferences in US and UK
    06-22-2007 · EurekAlert!
    Eighteen-year old Nicholas Tan Xue-Wei of Singapore is presenting stem cell research data at two intenational conferences.
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