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Pathway to cell death redefined in landmark study
09-20-2007 · EurekAlert!Researchers from the University of Pittsburgh School of Medicine have determined that an intracellular protein called serpin-6 is crucial to the repair and survival of cell injury. Controlling the process could pave the way to new treatments for cancer, stroke, heart disease, neurological disorders and other killer illnesses. Using a primitive animal model, the scientists also have made cascade of cell death and the role of serpin-6 in saving cells dramatically -- and explosively -- visible.
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Keywords: pathway, cell, death, redefined, landmark, study
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- Common anesthetic may induce cell death, generation of Alzheimer's-associated protein
02-06-2007 · EurekAlert!
A new study has found how one of the most commonly used anesthetics may produce Alzheimer's-like changes in the brain. Researchers from Massachusetts General Hospital and colleagues describe the mechanism by which the anesthetic isoflurane may induce both the cell-death process known as apoptosis and the generation of amyloid-beta protein in cultured neural cells.
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- Pre-operative high or low red blood cell count linked with poorer outcomes in older patients
06-12-2007 · EurekAlert!
Older patients with mild degrees of pre-operative anemia -- low red blood cell count -- or those with a very high red blood cell count have a higher risk of post-operative death or cardiac events following major noncardiac surgery, according to a study in the June 13 issue of JAMA.
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- Hot on the TRAIL of controlling inflammation in bacterial meningitis
06-14-2007 · EurekAlert!
In a study appearing online on June 14 in advance of publication in the July print issue of the Journal of Clinical Investigation, researchers at Charité-Universitätsmedizin Berlin report that the molecule known as TRAIL can limit excessive immune responses in bacterial meningitis, and as such may be of use to control inflammation of the spinal cord and brain, which causes brain cell death in this life-threatening disease.
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- Jefferson scientists find guardian gene's choices crucial to stopping cancer process
01-05-2007 · EurekAlert!
Scientists at the Kimmel Cancer Center at Thomas JeffersonUniversity have uncovered a novel pathway by which the anti-cancer gene p53 springs into action, protecting a damaged cell from becoming cancer. The gene can either halt the cell's growth or send it spiraling toward certain death. How this choice is made, the researchers say, could have implications for future strategies in chemotherapy drug development.
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- Females more prone to brain damage from alcohol abuse
07-25-2007 · EurekAlert!
Alcoholism has traditionally been considered a male disease because there are many more alcoholic males than females. But a study by researchers at Oregon Health & Science University and the Portland Veterans Affairs Medical Center suggests that women are more prone to brain damage from alcohol abuse than men. The study found that female mice are more susceptible to neurotoxic effects of alcohol withdrawal, including significantly increased brain cell death, than male mice.
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- New cell death pathway involved in sperm development
09-17-2007 · EurekAlert!
New research from Rockefeller University and the Howard Hughes Medical Institute uncovers a new pathway that regulates caspase activity in Drosophila sperm, a finding that may provide new opportunities to develop drugs that can alter cell death for therapeutic purposes.
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- Salk scientists hammer out a pathway that promotes muscle cell survival in mice
04-29-2007 · EurekAlert!
Scientists at the Salk Institute for Biological Studies have identified an enzyme that pumps up a cell's ability to maintain healthy muscle and restores normal muscle function in genetically engineered mice with weak muscles. The study, published online in Nature Medicine, is the first to explore the part this enzyme plays in a cascade of events triggered by exercise-induced hormones and other signals.
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- Scientists follow familiar TRAIL to new cancer therapy
07-09-2007 · EurekAlert!
A new study identifies a combination therapy that may sensitize human cancer cells to a promising treatment currently being used in clinical trials. The research, published in the July issue of the journal Cancer Cell, published by Cell Press, provides a pharmacological method for enhancing the potency and effectiveness of a tumor necrosis factor death receptor ligand against a variety of human cancers.
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- Cell pathway, disease linked to histone action
10-26-2007 · EurekAlert!
In the study a protein was identified that modifies H2A, which in turn regulates normal cell pathways and cell growth. When the function of this protein was blocked in tadpole embryos, the front-to-back body patterning was altered during maturation, according to researchers at the University of Alabama at Birmingham.
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- Pregnancy-related heart failure explained, symptoms reversed by simple hormone blocker
02-08-2007 · EurekAlert!
A new study reveals the mechanism responsible for a rare but potentially devastating form of heart failure that sometimes afflicts women late in pregnancy or shortly following childbirth, researchers have reported in the Feb. 9, 2007, issue of Cell, a publication of Cell Press. The so-called postpartum cardiomyopathy (PPCM) -- which is estimated to complicate one in every 1,300 to 4,000 deliveries in the US -- is considered among the leading causes of death among postpartum women in industrialized countries.
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