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Penn Veterinary Medicine report new strategy to create genetically modified animals
09-20-2007 · EurekAlert!Researchers at Penn Vet have demonstrated a new strategy for genetic modification of large animals by employing a virus that transfers genetic modifications to male reproductive cells, which passes naturally to offspring. Scientists at the Center for Animal Transgenesis and Germ Cell Research at Penn introduced adeno-associated virus to germline stem cells in goats and mice. AAV stably transduced male germ line stem cells and led to transgene transmission through the male germ line.
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Similar news on "Penn Veterinary Medicine report new strategy to create genetically modified animals":
- Penn Veterinary Medicine report new strategy to create genetically-modified animals
09-20-2007 · EurekAlert!
Researchers at Penn Vet have demonstrated a new strategy for genetic modification of large animals by employing a virus that transfers genetic modifications to male reproductive cells, which passes naturally to offspring. Scientists at the Center for Animal Transgenesis and Germ Cell Research at Penn introduced adeno-associated virus to germline stem cells in goats and mice. AAV stably transduced male germ line stem cells and led to transgene transmission through the male germ line.
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- Genetically modified carrots provide more calcium
01-14-2008 · EurekAlert!
Genetically modifying carrots to express increased levels of a gene that enables the transport of calcium across membranes of plant cells can make the vegetables a better source of calcium, said researchers at Baylor College of Medicine in Houston and the Vegetable and Fruit Improvement Center at Texas A&M University in a report that appears today in the Proceedings of the National Academy of Sciences.
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- Fighting HIV with HIV
11-06-2006 · EurekAlert!
Researchers at the University of Pennsylvania School of Medicine report the first clinical test of a new gene therapy based on a disabled AIDS virus carrying genetic material that inhibits HIV replication. For the first application of the new vector five subjects with chronic HIV infection who had failed to respond to at least two antiretroviral regimens were given a single infusion of their own immune cells that had been genetically modified for HIV resistance.
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- Penn study finds inhaled anesthetics accelerate the appearance of brain plaque in animals
03-09-2007 · EurekAlert!
Researchers at the University of Pennsylvania's School of Medicine have discovered that common inhaled anesthetics increase the number of amyloid plaques in the brains of animals, which might accelerate the onset of neurodegenerative diseases like Alzheimer's. Roderic Eckenhoff, MD, vice chair of Research in the University of Pennsylvania's Department of Anesthesia and Critical Care, and his co-authors, report their findings in the March 7 online edition of Neurobiology of Aging.
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- Snoozing worms help Penn researchers explain the evolution of sleep
01-11-2008 · EurekAlert!
Researchers report that the round worm has a sleep-like state, joining most of the animal kingdom in displaying this physiology. This research has implications for explaining the evolution and purpose of sleep and sleep-like states in animals, as well as identifying drug targets for sleep disorders.
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- Researchers create genetically matched embryonic stem cells for transplantation
12-14-2006 · EurekAlert!
Researchers at Children's Hospital Boston report a new and efficient strategy, using eggs alone, for creating embryonic stem (ES) cells that can generate tissues suitable for transplantation, because the cells are compatible with the recipient's immune system. The technique (done just in mice so far) would apply only to females, who would donate their own eggs to create genetically-matched ES cells.
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- Modified bone marrow cells can help recovery in an animal model of multiple sclerosis
04-09-2007 · EurekAlert!
A new study published in PLoS Medicine has shown that modified bone marrow cells can help recovery in an animal model of multiple sclerosis (MS).
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- Small-scale agricultural changes may help eradicate widespread disease
05-31-2007 · EurekAlert!
Small changes in agricultural and sanitation practices may eliminate the spread of a disease that affects some 200 million people living in developing nations around the world. Researchers working in remote farming villages in western China report that providing medicine to infected people and animals, along with modifying irrigation and waste treatment practices could reduce, or even eliminate, the long-term transmission of schistosomiasis.
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- Treatments for urinary infections leave bacteria bald, happy and vulnerable
12-20-2006 · EurekAlert!
A different approach to treating urinary tract infections (UTIs) could defeat the bacteria that cause the infections without directly killing them, a strategy that could help slow the growth of antibiotic-resistant infections. Researchers at Washington University School of Medicine in St. Louis have been working to create pharmaceuticals that essentially "defang" the bacteria by preventing them from assembling pili, microscopic hairs that enable the bacteria to invade host cells.
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- Animal research uncovers another mechanism of cholesterol lowering drug
06-14-2007 · EurekAlert!
New research in animals suggests why the commonly prescribed cholesterol-lowering drug ezetimibe (Zetia) is so potent. The research, reported by scientists at Wake Forest University School of Medicine, is reported online today by the Journal of Clinical Investigation and will appear in the July 2 print issue.
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