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A search for biomarkers for early detection of colorectal cancer

09-24-2007 · EurekAlert!

Using two-dimensional gel electrophoresis, 27 differentially expressed proteins were identified incolorectal adenoma, compared with individual-matched normal mucosa and cancer tissue. In those proteins, the differential expression of two novel proteins, mimecan and thioredoxin domain-containing protein 5 (TXNDC5), were validated by Western-blot. This study clearly demonstrated that absence of mimecan and up-regulation of TXNDC5 were involved in the early development of colorectal cancer.

Keywords: search, biomarkers, detection, colorectal, cancer, biomarker

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