Daily non-political popular news in brief.
Inside job: new radioactive agents for colon cancer work inside cells
10-09-2007 · EurekAlert!Johns Hopkins scientists have developed a potentially novel way to fight colorectal cancer using tiny molecules to deliver potent barrages of radiation inside cancer cells, unlike current treatments that bind to the surface of cells and attack from the outside and cause unwanted side effects.
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Keywords: job, radioactive, agents, colon, cancer, work, cells, agent, cell
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- Common cancer gene sends death order to tiny killer
05-31-2007 · EurekAlert!
Scientists at Johns Hopkins have discovered one way the p53 gene does what it's known for -- stopping the colon cancer cells. Their report will be published in the June 8 issue of Molecular Cell.
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- Tumor cells evade death through autophagy
01-18-2007 · EurekAlert!
Autophagy (a process that enables cells to turnover their contents) is initiated in tumor cells by chemotherapy and radiation, but it is not known if this causes tumor cell death or helps tumor cells survive. A new mouse study now indicates that autophagy is a survival mechanism for tumor cells treated with agents that initiate tumor cell death, suggesting that adjunct treatment with autophagy inhibitors might increase the efficacy of some chemotherapeutics in cancer patients.
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- Jefferson scientists find tumor suppressor gene protects against pre-cancerous development
11-01-2006 · EurekAlert!
Cell biologists have provided further evidence that a gene thought to play a role in suppressing tumors actually protects against the development of pre-cancerous cell growth as well. The researchers say that the gene, caveolin-1, which they found in two major types of breast cells, could be a potential target for future drugs aimed at preventing breast cancer. The work also suggests a potentially important role of the tumor "microenvironment" in the cancerous process.
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- Scientists prove that parts of cell nuclei are not arranged at random
10-19-2006 · EurekAlert!
The nucleus of a mammal cell is made up of component parts arranged in a pattern which can be predicted statistically, says new research published today. Scientists hope this discovery that parts of the inside of a cell nucleus are not arranged at random will give greater insight into how cells work and could eventually lead to a greater understanding of how they become dysfunctional in diseases like cancer.
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- New cancer weapon: nuclear nanocapsules
08-23-2007 · EurekAlert!
Rice University chemists have found a way to package some of nature's most powerful radioactive particles inside carbon nanotubes. Alpha-particle radiation is so powerful that cancer cells can be destroyed with just one direct hit from an alpha particle on a cell nucleus. Rice's researchers hope to use their new technology to target tiny tumors and even lone leukemia cells. Their research is available online from the journal Small.
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- New function for colon cancer gene found
01-17-2008 · EurekAlert!
Dartmouth Medical School geneticists have discovered a striking turnabout role for a gatekeeper known to put on the brakes for colon cancer. Flaws in a gene called adenomatous polyposis coli, which normally prevents excessive cell growth, are thought to trigger development of most colorectal cancers. But in an about face, the tumor suppressor gene also has a second task, the researchers found, as a gas pedal that accelerates signaling between cells.
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- Tumor-reactive T cells boosted by hematopoietic stem cell transplantation
02-01-2007 · EurekAlert!
Treatment for skin cancer by infusion of tumor-reactive T cells requires patients to be pre-treated with agents that transiently decrease the number of immune cells (nonmyeloablative agents). A study in mice now indicates that pre-treatment with more intense immune cell-depleting strategies (known as myeloablative strategies) and a hematopoietic stem cell transplant enables infused tumor-reactive CD8+ T cells to increase in number more than pre-treatment with nonmyeloablative agents, and this correlates with increased tumor regression.
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- Team finds way to create cancer stem cells
08-13-2007 · Massachusetts Institute of Technology (MIT)
MIT scientists and colleagues have found a way to create in the lab large amounts of cancer stem cells, or cells that can initiate tumors. The work, reported in the August 13 issue of Cancer Cell, could be a boon to researchers who study these elusive cells.
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- Molecular motors and brakes work together in cells
01-30-2007 · EurekAlert!
Researchers at the University of Pennsylvania School of Medicine have discovered that microtubules -- components responsible for shape, movement, and replication within cells -- use proteins that act as molecular motors and brakes to organize into their correct structure. If microtubules are not formed properly such basic functions as cell division and transport can go wrong, which may have implications in such disease processes as cancer and dementia.
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- Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
07-31-2007 · EurekAlert!
Working with human colorectal cancer cells, a University of Minnesota team, led by cancer biologists Zigang Dong and Ann Bode, has found the potential culprit among a network of enzymes that relay signals inside cells to regulate such functions as cell growth, cancer development and programmed cell death. The work suggests that drugs designed to disable the enzyme, known as TOPK, could have anticancer benefits. The study appears in the July issue of the journal Gastroenterology.
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