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Jefferson researchers find nanoparticle shows promise in reducing radiation side effects

With the help of tiny, transparent zebrafish embryos, researchers are hoping to prove that a microscopic nanoparticle can be part of a "new class of radioprotective agents" that help protect normal tissue from radiation damage just as well as standard drugs. They've shown that the nanoparticle, DF-1 -- a soccer ball-shaped, hollow, carbon-based structure known as a fullerene -- is as good as two antioxidant drugs and FDA-approved Amifostine in fending off radiation damage from normal tissue.

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1. Study: Re-engineered Gleevec reduces heart risks
   12-03-2007 · EurekAlert!
   Using a new bottom-up approach for rational drug design, researchers at Rice University and the University of Texas M. D. Anderson Cancer Center have reengineered the powerful anticancer drug imatinib -- best known by its brand name Gleevec -- to more specifically target one type of cancer while potentially curbing a rare life-threatening cardiotoxic side effect. The re-design strategy employed in the study is broadly applicable to reducing side effects in other drugs.
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2. Researchers propose reason for severe side-effects of Northwick Park clinical trial
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   A possible reason why the Northwick Park clinical trial of the drug TGN1412 in the UK caused multiple organ failure in human volunteers is revealed in research presented today at a conference near Paris. The research shows that stimulating the molecule CD28 on cells that mediate the immune response, known as T cells, can have an adverse effect if these immune cells have been activated and altered by infection or illness in the past.
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3. Weight-loss supplement shows good and bad traits
   01-30-2007 · EurekAlert!
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4. New study shows Rescue Remedy is an effective all-natural stress, anxiety reliever
   06-28-2007 · EurekAlert!
   A just published scientific study conducted by researchers at the University of Miami School of Nursing in conjunction with The Sirkin Creative Living Center (SCLC) has found that Rescue Remedy, an all-natural remedy created from flower essences, is an effective over-the-counter stress reliever with a comparable effect to traditional pharmaceutical drugs yet without any of the known adverse side effects, including addiction.
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5. Ski area affects mountain watershed, UVM study shows
   05-17-2007 · EurekAlert!
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   09-10-2007 · EurekAlert!
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