Daily non-political popular news in brief.

RNA-binding protein key to understanding myotonic dystrophy type 1

Increased levels of a protein called CUGBP1 play an important role in the adult-onset form of muscular dystrophy called myotonic dystrophy type 1, said Baylor College of Medicine researchers in a report that appears today in the journal Molecular Cell.

Read more »

Keywords: rna-binding, protein, key, understanding, myotonic, dystrophy, type, rna, binding

« Previous | Next »

Similar news on "RNA-binding protein key to understanding myotonic dystrophy type 1":

1. Mouse with myotonic dystrophy type 1 finds RNA binding proteins at heart of problem
   09-05-2007 · EurekAlert!
   A new mouse model for myotonic dystrophy - the most common form of adult-onset muscular dystrophy - helped Baylor College of Medicine researchers show that levels of CUGBP1, a protein that binds and controls the activity of the genetic material RNA, increase early in affected cells of the animals with the disease. This means CUGBP1 plays a key role in the disorder.
   Similar news · Read more »
   
2. Oregon team zeroes in on RNA-binding in myotonic dystrophy
   11-07-2007 · EurekAlert!
   University of Oregon researchers have shed new light on the function of an RNA-regulating protein known as muscleblind, which when it misbehaves and binds to rogue RNA can lead to disease affecting roughly one in 8,000 people.
   Similar news · Read more »
   
3. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
   08-15-2007 · EurekAlert!
   Scientists have discovered a key protein in the toxic brain pathway that leads to fragile X tremor/ataxia syndrome, an inherited neurodegenerative disorder. The finding, in a Drosophila (fly) model of FXTAS, could help unravel the complex mechanisms of FXTAS and lead scientists to develop therapies to target the protein.
   Similar news · Read more »
   
4. UVA reports surprising findings related to myotonic muscular dystrophy
   12-17-2007 · EurekAlert!
   New research from the University of Virginia Health System shows that, in cases of type 1 myotonic muscular dystrophy, a well known heart protein does several surprising things. The protein, NKX2-5, is a biomarker for heart stem cells. It is also very important for the normal development of the heart. The researchers were surprised to find that mice and individuals with DM1 actually overproduce NKX2-5, yet experience the same kind of heart problems associated with too little of it.
   Similar news · Read more »
   
5. RNA splicing factor implicated in ovarian tumor cell growth
   04-09-2007 · EurekAlert!
   An RNA-binding protein that is overproduced in ovarian cancer may present a new target for diagnosis or treatment of ovarian and other cancers, according to researchers at the University of Illinois at Chicago.
   Similar news · Read more »
   
6. Enzyme structure reveals new drug targets for cancer and other diseases
   02-14-2008 · EurekAlert!
   Researchers now have a clearer understanding of how a key protein controls gene activity and how mutations in the protein may cause disease. The work could provide new avenues to design drugs aimed at cancer, diabetes, HIV, and heart disease.
   Similar news · Read more »
   
7. Animal BiP levels determine amount of recovery sleep needed following prolonged wakefulness
   05-01-2007 · EurekAlert!
   Immunoglobulin binding protein in animals, a key indicator of endoplasmic reticulum stress, is instrumental in determining the amount of recovery sleep following enforced wakefulness, according to a study published in the May 1 issue of the journal Sleep.
   Similar news · Read more »
   
8. How blood flow dictates gene expression
   12-20-2006 · EurekAlert!
   Researchers at the University of Pennsylvania School of Medicine have pinpointed a key regulatory protein that translates blood flow into gene expression. The investigators showed that in a model of mouse embryonic development a transcription factor called Klf2, which resides in cells that line blood vessels, is activated by rapid, pulsed blood flow. Understanding Klf2's role in blood vessel and muscle biology could help with fighting atherosclerosis.
   Similar news · Read more »
   
9. Transplanted cells may hold the key to curing hemophilia A, Einstein scientists report
   02-14-2008 · EurekAlert!
   Scientists at the Albert Einstein College of Medicine have shown for the first time that transplanted cells can cure hemophilia A (the most common form of the disease) in an animal model. To do so, the researchers transplanted healthy liver endothelial cells from donor mice into a mouse model of the disease. Their findings also overturned conventional wisdom regarding which cells produce factor VIII, the crucial clotting protein that people with type A hemophilia lack.
   Similar news · Read more »
   
10. Math model could aid study of collagen ailments
    11-14-2006 · EurekAlert!
    An MIT researcher's mathematical model explains for the first time the distinctive structure of collagen, a material key to healthy human bone, muscles and other tissues. The new model shows collagen's structure from the atomic to the tissue scale. An improved understanding of nature's most abundant protein could aid the search for cures to such ailments as osteoporosis and scurvy, all recognized as arising from diseased collagen.
    Similar news · Read more »