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Sidestepping cancer's chaperone

Researchers at the University of Massachusetts Medical School, have defined a method to target and kill cancer's 'chaperone' -- a protein that promotes tumor cell stability and survival -- without damaging healthy cells nearby.

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Keywords: sidestepping, cancer, chaperone

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1. Researchers find level of special protein is critical to proper formation of muscles
   04-23-2007 · EurekAlert!
   Proper formation of the proteins that power heart and skeletal muscle seems to rely on a precise concentration of a "chaperone" protein known as UNC-45, according to a new study.This basic discovery may have important implications for understanding and eventually treating heart failure and muscle wasting elsewhere in the body resulting from burns, brain trauma, diabetes, cancer and the effects of aging.
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2. Gene Signatures Match Cancer And Other Diseases With Potentially Effective Drugs
   09-29-2006 · ScienceDaily
   In one of the most ambitious spinoffs of the human genome project, researchers at Dana-Farber Cancer Institute, Children's Hospital Boston, the Broad Institute of Harvard and MIT, and other collaborating centers have unveiled a new, systematic approach to drug discovery that matches diseases with potential treatments using a universal language based on cells' distinctive gene activity profiles, or "signatures."
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3. Exercise Helps Breast Cancer Patients Avoid Anemia
   10-09-2006 · ScienceDaily
   Women undergoing radiation treatment for breast cancer benefit from moderate intensity, regular aerobic activity, according to a new study. The study found that exercise improved the oxygen capacity of patients and maintained levels of red blood cells during radiation treatment.
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4. Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack
   10-16-2006 · EurekAlert!
   Mass vaccination would not be necessary in the event of a large-scale smallpox bioterrorist attack in the United States, according to researchers at Fred Hutchinson Cancer Research Center.
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5. Study offers innovative profile of enzyme that aids tumor growth
   10-20-2006 · EurekAlert!
   Using an innovative profiling strategy, scientists at the Scripps Research Institute have characterized an enzyme that is "highly elevated" in aggressive human tumor cells. When the enzyme, KIAA1363, was inactivated, it impaired tumor growth and migration in both ovarian and breast cancer cells, suggesting that inhibitors of this enzyme may prove valuable in the treatment of multiple types of cancer.
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6. Trimming Down Cancer: Fat could hinder body's fight against disease
   10-28-2006 · Science News Online
   Fatty tissue may secrete substances that make it harder for the body to battle cancer.
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7. Antiprotons 4 times more effective than protons for cell irradiation
   10-31-2006 · EurekAlert!
   A pioneering experiment at CERN with potential future application in cancer therapy has produced its first results. Started in 2003, ACE (Antiproton Cell Experiment) is the first investigation of the biological effects of antiprotons.
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8. Low folate diets found to increase risk of colorectal cancer
   11-02-2006 · EurekAlert!
   A new study by scientists at the MUHC has revealed that a diet low in folate may increase the risk of developing colorectal cancer. Published in the scientific journal Cancer Research today, the study not only illustrates a way to prevent the disease but also provides further insight into the mechanisms of the disease, which could lead to novel therapies.
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9. Intravenous chemoradiation effective for inoperable head, neck cancer; easier for patients, doctors
   11-06-2006 · EurekAlert!
   Chemoradiation (radiation and chemotherapy given at the same time) given through a needle or tube inserted into a vein (intravenous) is as effective as treatment given directly to the tumor through a tube inserted into an artery (intra-arterial) for patients with inoperable head and neck cancer, according to a randomized study presented at the plenary session November 6, 2006, at the American Society for Therapeutic Radiology and Oncology's 48th Annual Meeting in Philadelphia.
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10. Drug that interrupts a key stage of cell division shows promise for advanced solid tumors
    11-08-2006 · EurekAlert!
    One of the first studies to investigate the effects of a new anti-cancer drug in patients with advanced or metastatic solid tumours has shown that it is capable of halting progression of the disease, and the study has provided the first proof of the drug's mechanism of action, the 18th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Prague was told on Wednesday.
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