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Orexigen: Laboratory studies show Contrave acts on specific brain pathways to reduce food intake
10-23-2007 · EurekAlert!Laboratory studies show the combination of bupropion and naltrexone (the components of Contrave) acts in a part of the brain where food reward pathways are located and resulted in a 95 percent reduction in food intake in obese mice. This mechanism of action may differentiate Contrave from other obesity therapeutics. Concurrent with these studies, Contrave is in phase 3 clinical trials.
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Keywords: orexigen, laboratory, studies, show, contrave, acts, specific, brain, pathways, food, intake, study, act, pathway
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- Food Restriction Increases Dopamine Receptor Levels in Obese Rats
10-25-2007 · Brookhaven National Laboratory
A brain-imaging study of genetically obese rats conducted at Brookhaven provides more evidence that dopamine - a brain chemical associated with reward, pleasure, movement, and motivation - plays a role in obesity. Scientists found that genetically obese rats had lower levels of dopamine D2 receptors than lean rats. They also demonstrated that restricting food intake can increase the number of D2 receptors, partially attenuating a normal decline associated with aging.
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- 2 heads are better than 1: 2 dysfunctional DNA repair pathways kill tumor cells
04-12-2007 · EurekAlert!
Individuals who inherit one mutant copy of any one of about 12 genes that make the proteins of the Fanconi Anemia pathway are at increased risk of developing cancer. This occurs when the remaining "good" copy of the gene becomes mutated in a specific cell type. However, hope of a new treatment for these cancers has now been provided by a new study indicating that inhibiting the protein ATM can kill these cancer cells.
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- Study shows interruption of antiretroviral therapy increases risk of disease and death
11-30-2006 · EurekAlert!
Findings from one of the largest HIV/AIDS therapy studies show that a specific strategy of interrupting antiretroviral therapy more than doubles the risk of AIDS or death from any cause. Researchers affiliated with the Mailman School of Public Health led a large multi-center international study, known as Strategies for Management of Anti-Retroviral Therapies, or SMART, comparing two treatment strategies for people with human immunodeficiency virus. Findings demonstrate the value of continuous antiretroviral therapy.
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- Adult brain can change, study confirms
09-05-2007 · Massachusetts Institute of Technology (MIT)
Neuroscientists from MIT and Johns Hopkins University have used evidence from brain imaging and behavioral studies to show that the adult visual cortex reorganizes--and that the change affects visual perception.
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- Leptin Has Powerful Effect On Reward Center In The Brain
09-29-2006 · ScienceDaily
Leptin, a hormone critical for normal food intake and metabolism, exerts a strong effect on appetite by acting in the mid-brain region as well as in the hypothalamus, according to a Yale School of Medicine study in Neuron.
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- Revealing estrogen's secret role in obesity
08-20-2007 · EurekAlert!
Research on the effects of the female sex hormone estrogen in the brain lend credence to what many women have suspected about the hormonal changes that accompany aging: Menopause can make you fat. In animal experiments, researchers showed how estrogen receptors in the brain serve as a master switch to control food intake, energy expenditure and body fat distribution. The study will be presented in August at the American Chemical Society national meeting in Boston.
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- Tea helps treat damaged skin in cancer patients
11-30-2006 · EurekAlert!
Tea extracts work as an effective treatment for patients who suffer from damaged skin following radiation treatment for cancer. Researchers show that this might partly be due to the anti-inflammatory properties of tea. In a study published today in the open access journal BMC Medicine, researchers show that tea acts at the cellular level, by inhibiting inflammatory pathways, to reduce inflammation.
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- Stress triggers relapse in meth abuse, OHSU study finds
10-18-2006 · EurekAlert!
Oregon Health & Science University research showing stress triggers relapse of methamphetamine abuse in mice could be a step toward developing a drug to curb this frustrating obstacle to recovery. Results of the study not only validate earlier studies on the effects of stress on drug relapse in humans, they also show a compound researchers used to mimic metabolic changes that occur during stress creates a useful model for studying this effect in the laboratory.
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- This is your brain on violent media
12-05-2007 · EurekAlert!
Columbia scientists show that a brain network responsible for suppressing behaviors like inappropriate or unwarranted aggression became less active after study subjects watched several short clips from popular movies depicting acts of violence. These changes could render people less able to control their own aggressive behavior.
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- New neuroimaging study identifies 'brain signature' for cigarette cravings
12-18-2007 · EurekAlert!
A new brain imaging study by researchers in the Abramson Cancer Center of the University of Pennsylvania shows that cigarette cravings in smokers who are deprived of nicotine are linked with increased activation in specific regions of the brain. Using a novel method of measuring brain blood flow developed at Penn, this study is the first to show how abstinence from nicotine produces brain activation patterns that relate to urges to smoke.
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