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Researchers discover important tool in understanding differentiation in human embryonic stem cells

10-24-2007 · EurekAlert!

Researchers at the University of Minnesota's Stem Cell Institute have used an existing genetic tool to study how human embryonic stem cells self-renew. The researchers used "knockdown" technology to reduce the expression, and plasmid vectors to increase the expression of oct4, a gene known to be necessary for self renewal. Both procedures resulted in differentiation, but with similar patterns, unlike mouse ES cells that differentiate into a different cell types with oct4 up-and down-regulation.

Keywords: researchers, discover, important, tool, understanding, differentiation, human, embryonic, stem, cells, researcher, cell

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