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Targets on the horizon: Emerging therapies and novel targets
10-25-2007 · EurekAlert!What are the cancer drugs of tomorrow and how will they be developed? Today, at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, researchers will present some answers to these and other pressing questions regarding emerging cancer therapeutics.
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Keywords: targets, horizon, emerging, therapies, novel, target, therapy
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- Study shows liver an excellent target for cancer gene therapy using viral vectors
02-14-2007 · EurekAlert!
A featured paper in the Feb. 14 issue of Nature Cancer Gene Therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors, based upon a fundamental new understanding of the differences between cancerous and normal liver cells. The findings signal a new way to treat cancers that have spread to the liver, such as metastatic cancers of the colon and breast.
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- Jefferson researchers boost immune 'killer cells,' increase antibody effectiveness against cancer
04-18-2007 · EurekAlert!
Researchers have devised a novel method to expand the number of immune system "natural killer (NK)" cells from blood cells outside the body. They have shown in laboratory studies that adding such cells to anti-cancer therapies involving monoclonal antibody drugs such as Herceptin, which targets the HER2/neu protein on breast cancer cells, is more effective in killing cancer cells, and perhaps someday may improve treatments.
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- Discovery of widespread tumor growth gene holds promise for effective anti-cancer treatment
09-23-2007 · EurekAlert!
Italian scientists will announce on Monday (Sept. 24) that they have found a new and promising target for anti-tumor therapy in cancer. Professor Saverio Alberti, from the CESI, University of Chieti Foundation, Chieti, will tell the European Cancer Conference that he and his team have found a widespread mechanism for the stimulation of tumor growth in man, and that this is leading to the development of novel diagnostic and therapeutic procedures.
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- Animal study identifies promising new target for brain tumor therapy
05-08-2007 · EurekAlert!
A drug that targets the body's immune cells may be effective in treating malignant brain tumors, according to a new study led by researchers from Duke's Preston Robert Tisch Brain Tumor Center. In animal models, the drug re-engaged the body's cancer-damaged immune system.
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- Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
08-13-2007 · EurekAlert!
Two new studies may lead to the development of more effective therapies for individuals with multiple myeloma, a common and incurable blood cell cancer. The research, published by Cell Press in the August issue of the journal Cancer Cell, provides new insight into the molecular mechanisms that underlie aberrant NF-κB activity in MM tumor cells and underscores the relevance of the signaling pathway as a target for MM therapy.
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- Protein therapy may reduce infarct size in heart attack patients
03-25-2007 · EurekAlert!
Researchers are searching for new methods and therapies to reduce infarct size and improve blood flow to the heart muscle in patients who experience myocardial infarction (MI), or heart attack. In a study presented today at the American College of Cardiology's Innovation in Intervention: i2 Summit in New Orleans, La., a team from the Duke Clinical Research Institute presented the results from a Phase 1 study evaluating a novel protein kinase C inhibitor.
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- Researchers identify protein pathway involved in Parkinson disease development
06-18-2007 · EurekAlert!
Scientists have found a novel signaling pathway in cells that is altered by genetic mutations recently identified in Parkinson disease development. These new findings show how the mutations affect cellular function and could provide a target for drug therapies to treat the disease.
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- Clinical studies in the pipeline: the therapies of tomorrow in trials today
10-23-2007 · EurekAlert!
Studies presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics demonstrate the flexibility of targeted therapy techniques, where new drugs can be developed and tested in human trials more quickly and safely than ever before.
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- Novel platelet therapy may reduce PCI complications
03-24-2007 · EurekAlert!
Despite the availability of numerous antithrombotic therapies, adverse events following percutaneous coronary intervention such as late-stent thrombosis are still a concern for cardiologists, and there's a need for medications that can minimize the risk of these complications but also manage the rate of bleeding. A study presented today at the American College of Cardiology's Innovation in Intervention: i2 Summit evaluates the safety and efficacy of a novel oral thrombin receptor antagonist in reducing PCI complications.
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- Phase I pharmacokinetic study of ECO-4601, a novel bifunctional targeting agent
10-24-2007 · EurekAlert!
A first-in-class, targeted investigational therapy specifically designed to inhibit a single protein that functions only during cell division shows potent activity in a broad range of cancer cell lines, say researchers presenting at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics.
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