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Intravenous gene therapy protects normal tissue of mice during whole-body radiation
10-28-2007 · EurekAlert!Gene therapy administered intravenously could be used as an agent to protect vital organs and tissues from the effects of ionizing radiation in the event of large-scale exposure from a radiological or nuclear bomb. In the University of Pittsburgh study, mice were used to test the protective effects of manganese superoxide dismutase plasmid liposome gene therapy on the bone marrow during whole-body irradiation.
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Keywords: intravenous, gene, therapy, protects, normal, tissue, mice, whole-body, radiation, intravenou, protect, whole, body
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Similar news on "Intravenous gene therapy protects normal tissue of mice during whole-body radiation":
- Intravenous gene therapy protects normal tissue of mice during whole-body radiation
11-07-2006 · EurekAlert!
Gene therapy administered intravenously could be used as an agent to protect vital organs and tissues from the effects of ionizing radiation in the event of large-scale exposure from a radiological or nuclear bomb. In the University of Pittsburgh study, mice were used to test the protective effects of manganese superoxide dismutase plasmid liposome (MnSOD-PL) gene therapy on the bone marrow during whole-body irradiation.
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- Enzyme delivered in smaller package protects cells from radiation damage
06-01-2007 · EurekAlert!
A University of Pittsburgh School of Medicine research team, collaborating with scientists from Stanford University, have developed a new, smaller gene therapy vector that may be effective in delivering a radioprotective enzyme systemically throughout the body which may spare healthy tissue the long-term consequences of therapeutic irradiation. These results also have implicatons for protecting first responders to a nuclear accident or terrorist attack.
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- Fragile X retardation syndrome corrected in mice
12-19-2007 · EurekAlert!
Researchers working with mice have significantly alleviated a wide range of abnormalities due to fragile X syndrome by altering only a single gene, countering the effects of the fragile X mutation. They said their achievement offers the potential for treatment of the disorder, the most common form of inherited mental retardation and a leading identified genetic cause of autism. There is currently no treatment or therapy for fragile X syndrome, whose symptoms include mental retardation, epilepsy and abnormal body growth.
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- Gene protects adults abused as children from depression
02-04-2008 · EurekAlert!
Some forms of a gene that controls the body's response to stress hormones appear to protect adults who were abused in childhood from depression, psychiatrists have found. People who had been abused as children and who carried the most protective forms of the gene, called corticotropin-releasing hormone receptor one, had markedly lower measures of depression, compared with people with less protective forms.
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- Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
11-08-2006 · EurekAlert!
With the help of tiny, transparent zebrafish embryos, researchers are hoping to prove that a microscopic nanoparticle can be part of a "new class of radioprotective agents" that help protect normal tissue from radiation damage just as well as standard drugs. They've shown that the nanoparticle, DF-1 -- a soccer ball-shaped, hollow, carbon-based structure known as a fullerene -- is as good as two antioxidant drugs and FDA-approved Amifostine in fending off radiation damage from normal tissue.
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- A transplant in time
12-28-2006 · EurekAlert!
In hemophilia, a mutated gene prevents the production of a blood-clotting protein. Treatments for hemophilia and other genetic diseases may consist of risky blood transfusions or expensive enzyme replacement therapy. But what if the body could be induced to begin producing these proteins by transplanting healthy tissue with the abilities that are lacking? The Weizmann Institute's Immunology Department showed how such a transplant might be made feasible.
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- Gene therapy can reduce long-term drinking among rodents
01-03-2008 · EurekAlert!
In this issue: Certain genetic factors may both increase and protect against the risk of developing alcoholism; The aldehyde dehydrogenase (ALDH2*2) allele is considered protective against alcoholism; and Intravenous administration of an anti-Aldh2 antisense gene can curtail long-term drinking among rodents.
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- Loss of stem cells correlates with premature aging in animal study
06-06-2007 · EurekAlert!
Researchers at the Abramson Family Cancer Research Institute of the University of Pennsylvania have found that deleting a gene important in embryo development leads to premature aging and loss of stem cell reservoirs in adult mice. This gene, ATR, is essential for the body's response to damaged DNA, and mutations in proteins in the DNA damage response underlie certain types of cancer and other disorders in humans.
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- Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer
04-17-2007 · EurekAlert!
A cancer-suppressing gene has been successfully delivered into the tumors of stage four lung cancer patients via an intravenously administered lipid nanoparticle in a phase I clinical trial at the University of Texas M. D. Anderson Cancer Center. The gene, FUS1, also was found to be active in the metastatic nonsmall cell lung cancer tumors.
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- Scripps research combination therapy obliterates new vessel growth in tumors and retinopathy
01-09-2007 · EurekAlert!
Using a new and dramatically effective treatment approach, scientists at the Scripps Research Institute have for the first time achieved complete inhibition of new blood vessel growth in animal models of a highly vascular brain tumor and of neovascular eye diseases with little or no effect on normal tissue vasculature.
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