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Scientists unveil structure of molecular target of many drugs
10-29-2007 · EurekAlert!Scientists have captured the first detailed, three-dimensional look at the beta2-adrenergic receptor -- a human G protein-coupled receptor belonging to a family of membrane proteins targeted by about half of today's pharmaceuticals.
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Keywords: scientists, unveil, structure, molecular, target, many, drugs, scientist, drug
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- Translating form into function
07-01-2007 · EurekAlert!
In the last 40 years, scientists have perfected ways to determine the knot-like structure of enzymes, but they've been stumped trying to translate the structure into an understanding of function -- what the enzyme actually does in the body. This puzzle has hurt drug discovery, since many of the most successful drugs work by blocking enzyme action. Now, in an expedited article in Nature, researchers show that a solution to the puzzle is finally in sight.
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- Telomerase enzyme structure provides significant new target for anti-cancer therapies
11-13-2007 · EurekAlert!
Inappropriate activation of a single enzyme, telomerase, is associated with the uncontrollable proliferation of cells seen in as many as 90 percent of all of human cancers. Scientists have long eyed the enzyme as an ideal target for developing broadly effective anti-cancer drugs. Now, researchers working at the Wistar Institute have brought this goal closer by deciphering the 3-D structure of a domain, or region, of the telomerase molecule essential for the enzyme's activity.
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- Weill Cornell team identifies potential new cancer drug target
06-21-2007 · EurekAlert!
Research led by scientists at Weill Cornell Medical College has uncovered two new potential points of vulnerability on a key cancer-promoting protein, called XIAP. Drugs that target either of these activities could help push cancer cells back into a more regular programmed cell death and thereby reduce or eliminate tumors.
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- Key Function Of Nervous System Enzyme Found; Impact On Drug Development Against Alzheimer's
09-29-2006 · ScienceDaily
Ever since scientists first elucidated the molecular mechanisms underlying the pathology and loss of nerve cells in Alzheimer's disease, drug companies have been working to develop drugs which will inhibit the outbreak of this severe form of dementia. Now researchers in Munich and Berlin (Germany) have discovered that an enyzme which has a central causal role in Alzheimer's disease happens also to have a key function in the normal development of the nervous system. This enzyme, beta-secretase or BACE1, ensures that nerve fibers (axons) are adequately isolated with sheaths of myelin, enabling rapid conduction of electrical impulses, as well as preventing short-circuits, akin to plastic insulation on electrical wires.
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- Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
08-20-2007 · EurekAlert!
Carnegie Mellon University scientists have developed tiny, spherical nanogels that uniformly release encapsulated carbohydrate-based drugs. The scientists created the nanogels using atom transfer radical polymerization, which will ultimately enable the nanogels to deliver more drug directly to the target and to dispense the drug in a time-release manner.
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- 'Knocking out' cell receptor may help block fat deposits in tissues, prevent weight gain
10-25-2007 · EurekAlert!
University of Cincinnati pathologists have identified a new molecular target that one day may help scientists develop drugs to reduce fat transport to adipocytes in the body and prevent obesity and related disorders, like diabetes.
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- UCF scientists' molecular discovery could help drugs target unhealthy cells
01-18-2007 · EurekAlert!
University of Central Florida and University of California Riverside professors are a step closer to being able to deliver life-saving drugs through tiny molecules that would travel through the bloodstream and destroy only cancer-ridden cells.
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- Penn researchers discover new target for preventing and treating flu
01-30-2008 · EurekAlert!
Researchers at the University of Pennsylvania School of Medicine have now provided a new strategy for designing drugs that target resistant viral strains of inflenza tupe A by solving the three-dimensional structure of a viral protein called the M2 proton channel. This protein is the molecular receptor for these drugs.
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- Bacterial walls come tumbling down
03-09-2007 · EurekAlert!
The first detailed images of an elusive drug target on the outer wall of bacteria may provide scientists with enough new information to aid design of novel antibiotics. The drugs are much needed to treat deadly infections initiated by Staphylococcus aureus and other bacterial pathogens.
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- Brown scientists map structure of DNA-doctoring protein complex
12-06-2006 · EurekAlert!
Mobile DNA, which inserts foreign genes into target cells, is a powerful force in the march of evolution and the spread of disease. Working with the lambda virus and E. coli bacteria, Brown University biologists have solved the structure of a six-protein complex critical to performing this gene-grafting surgery. The technique they developed could be used to reveal the structure of other critical protein complexes, landing the work on the cover of Molecular Cell.
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