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Speed plays crucial role in breaking protein's H-bonds
10-30-2007 · EurekAlert!Researchers at MIT studying the architecture of proteins have finally explained why computer models of proteins' behavior under mechanical duress differ dramatically from experimental observations. This work could have vast implications in bioengineering and medical research by advancing our understanding of the relationship between structure and function in these basic building blocks of life.
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Keywords: speed, plays, crucial, role, breaking, protein, h-bonds, play, bonds
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- Speed is crucial in breaking protein's H-bonds
11-07-2007 · Massachusetts Institute of Technology (MIT)
By slowing down the application of pressure in atomistic models, MIT researchers studying the architecture of proteins have explained why computer models of proteins' behavior under mechanical duress differ from experimental observations.
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- Researchers identify cell pathway in colon cancer
02-20-2007 · EurekAlert!
Researchers have identified a cell pathway which plays a critical role in the development of colon cancer. This pathway may also play a role in the development of lung and stomach cancers. Investigators say they have identified STAT3 {signal transducer and activator of transcription 3}, as a target regulated by PTPRT {Receptor Protein tyrosine phosphatase T}, which was previously identified to be mutated in colon, lung and stomach cancer patients.
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- Cystic fibrosis proteins photographed interacting
12-07-2007 · EurekAlert!
New microscopic pictures show the first-ever physical evidence of interaction between two proteins involved in cystic fibrosis (CF) disease. UAB studied a CF-causing protein and another protein called epithelial sodium channel, or ENaC. Both proteins are known to play a role in CF, but exactly what role each plays is unclear.
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- Detailed 3-D image catches a key regulator of neural stem cell differentiation in action
12-07-2006 · EurekAlert!
Researchers at the Salk Institute for Biological Studies in collaboration with scientists at the University of California, San Diego took a high resolution "action shot" of a protein switch that plays a crucial role in the development of the nervous system. Their findings, published in the December 8 issue of the journal Molecular Cell, provide a template for the design of small molecule inhibitors to control that switch, a protein called Scp1, at will.
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- Antarctic ice sheet's hidden lakes speed ice flow into ocean, may disrupt climate
03-06-2007 · EurekAlert!
In a new study, researchers have unearthed how water from a vast subglacial system contributes to the formation of ice streams, and how it plays a crucial role in transporting ice from the remote interior of Antarctica toward the surrounding ocean. Water flowing from this network of under-ice lakes, they say, ultimately affects climate and global sea level.
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- Zinc Transporter Protein Structure Deciphered
08-23-2007 · Brookhaven National Laboratory
Scientists at Brookhaven have deciphered the atomic-level structure of a cell-membrane protein that regulates the movement of zinc ions into and out of cells. Details of the structure may help scientists better understand the crucial role zinc plays in many biological process, from nerve cell communication to insulin regulation.
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- Gene found to play a suppressor role in skin cancer development
02-06-2008 · EurekAlert!
Researchers at the Burnham Institute for Medical Research have provided genetic evidence that Activating Transcription Factor 2 plays a suppressor role in skin cancer development. ATF2 is a protein that regulates gene transcription, the first step in the translation of genetic code, in response to extracellular stresses such as ultraviolet light and ionizing radiation. This function of ATF2 in stress and DNA damage response suggests it may also play a role in tumor formation.
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- Alzheimer's molecule is a smart speed bump on the nerve-cell transport highway
01-17-2008 · EurekAlert!
Researchers at the University of Pennsylvania School of Medicine discovered that proteins carrying chemical cargo in nerve cells react differently when exposed to the tau protein, which plays an important role in Alzheimer's disease.
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- Taking heart failure to the MAT1
02-06-2007 · EurekAlert!
A gene called mйnage-а-trois 1, or MAT1, plays a crucial role in the function of a master switch for production of energy in the heart cell -- a finding that has important implications for understanding and maybe even treating heart failure.
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- Team proves role of microRNAs in spread of cancer
09-27-2007 · Massachusetts Institute of Technology (MIT)
MIT scientists have proved that microRNAs, tiny molecules that fine-tune protein production and play a powerful role in biological processes, can prompt otherwise sedentary cancer cells to move and invade other tissues.
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