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Pourquie Lab demonstrates role of growth factor in vertebrae formation
10-30-2007 · EurekAlert!The Stowers Institute's Pourquie Lab has demonstrated the role of fibroblast growth factor in the embryonic process of somitogenesis, an event required for vertebrae formation, in a paper posted to the Web site of the journal Development. The paper will appear in the November print issue of the journal.
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- Conaway Lab demonstrates mechanism by which transcription factor controls gene expression
08-27-2007 · EurekAlert!
The Conaway Lab -- led by Joan Conaway, Ph.D., and Ron Conaway, Ph.D., investigators -- has published findings that shed light on the role of the much-studied transcription factor YY1 in gene expression. Yong Cai, Ph.D., research specialist I, and Jingji Jin, Ph.D., senior research associate, are the paper's coequal first authors.
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- Contribution of cholesterol transporter to vascular disease
10-25-2007 · EurekAlert!
Low-density lipoprotein, a transporter of cholesterol, may also contribute to vascular diseases by a previously unidentified mechanism, according to a report published online this week in EMBO reports. The study reveals a link between native LDL and the vascular endothelial growth factor receptor 1, which plays a central role in blood vessel formation.
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- Xie Lab demonstrates the role of microRNA pathway
02-15-2007 · EurekAlert!
Ting Xie, Ph.D., associate investigator, and Zhigang Jin, Ph.D., postdoctoral research associate in the Xie Lab, have published results showing that the microRNA pathway is essential for controlling self-renewal of germline stem cells and somatic stem cells in the Drosophila ovary.
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- 'Gateway' gene discovered for brain cancer
02-14-2007 · EurekAlert!
Researchers have discovered that the same genetic regulator that triggers growth of stem cells during brain development also plays a central role in the development of the lethal brain cancer malignant glioma. In experiments on mice with such gliomas, they showed that knocking out the function of a particular regulatory protein, Olig2, almost completely eliminated tumor formation.
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- Carnegie Mellon University-led team conducts most detailed cosmological simulation to date
06-28-2007 · EurekAlert!
Using a new computer model of galaxy formation, researchers have shown that growing black holes release a blast of energy that fundamentally regulates galaxy evolution and black hole growth itself. The model explains for the first time observed phenomena and promises to deliver deeper insights into our understanding of galaxy formation and the role of black holes throughout cosmic history. The results were generated by an international team of investigators.
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- Researchers specifically manipulate tumor angiogenesis gene
10-13-2007 · EurekAlert!
Vascular endothelial growth factor is secreted by most tumors and has been shown to play an important role in tumor angiogenesis. RNAi is the sequence-specific, posttranscriptional gene silencing method initiated by double-stranded RNAs. We planned to find a better VEGF specific RNAi for colon cancer.
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- Eltrombopag studied in Idiopathic Thrombocytopenic Purpura
11-28-2007 · EurekAlert!
There are estimated to be between 50,000-100,000 individuals in the US diagnosed with chronic Immune Thrombocytopenic Purpura, an autoimmune disease that dramatically reduces the number of platelets in their blood -- causing bruises, nosebleeds and, sometimes, life-threatening brain hemorrhages. Now, the results of an international multicenter clinical research study led by NewYork-Presbyterian Hospital/Weill Cornell Medical Center demonstrate that an investigational oral platelet growth factor called eltrombopag successfully increased platelet counts and decreased bleeding in patients with the condition.
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- Lymphatic vessel and lymph node function are restored with growth factor treatment
12-02-2007 · EurekAlert!
The frequent spread of certain cancers to lymph nodes often necessitates surgery or radiation therapy that damages the lymphatic system. The study of the researchers at the University of Helsinki, Finland, published in Nature Medicine, demonstrate for the first time that growth factor therapy, combined with lymph node transplantation, allows for complete restoration of the lymphatic system in damaged tissues, and provides a working model for future treatment of lymphedema in patients.
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- Role of TRPM8 in the development of prostate cancer
05-17-2007 · EurekAlert!
In normal prostate epithelium, cells coexist in many stages of development-differentiation, and disrupted differentiation and proliferation are major causes of cancer. A new study shows that the endoplasmic reticulum protein TRPM8 (ER-TRPM8) present in human prostate epithelial luminal cancer cells retains it’s function as a calcium release channel, independent of the differentiation state of the cell, and may be an important factor in controlling the growth of prostate cancer cells.
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- Atmospheric Measuring Device for Understanding Smog Formation
11-19-2007 · Brookhaven National Laboratory
Scientists at Brookhaven Lab have developed a new tool for quantitatively measuring elusive atmospheric chemicals that play a key role in the formation of photochemical smog. Better measurements will improve scientists' understanding of the mechanisms of smog formation and their ability to select and predict the effectiveness of various mitigation strategies.
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