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Vitamin A derivative associated with reduced growth in some lung cells
10-30-2007 · EurekAlert!Treatment with a derivative of vitamin A called retinoic acid was associated with reduced lung cell growth in a group of former heavy smokers, according to a study published online Oct. 30 in the Journal of the National Cancer Institute.
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Keywords: vitamin, derivative, associated, reduced, growth, lung, cells, cell
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- Chemical compound found in tree bark stimulates growth, survival of brain cells
10-01-2007 · EurekAlert!
Researchers have identified a compound in tree bark that mimics the chemical reactions of a naturally occurring molecule in the brain responsible for stimulating neuronal cell signaling. The tree bark compound, known as gambogic amide, behaves much like Nerve Growth Factor, a molecule found in the brain. NGF binds to TrkA, a neuronal receptor, and activates neuronal signaling. It is known that the loss of TrkA density correlates with neuronal atrophy and severe cognitive impairment such as that associated with Alzheimer's disease.
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- Study reveals how some molecules inhibit growth of lung cancer cells
03-12-2007 · EurekAlert!
By mapping the interlocking structures of small molecules and mutated protein "receptors" in non-small cell lung cancer (NSCLC) cells, scientists at Dana-Farber Cancer Institute and their colleagues have energized efforts to design molecules that mesh with these receptors, potentially interfering with cancer cell growth and survival.
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- Pro-vitamin E shown to be active against breast cancer cells
12-07-2006 · EurekAlert!
A precursor of vitamin E has been shown to be effective against breast cancer cell lines which over-express human epidermal growth factor receptor (HER2).
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- Brain cell growth diminishes long before old age strikes, animal study shows
10-15-2007 · EurekAlert!
Soon after marmosets reach adulthood, the rate at which new neural cells form in the hippocampus region of the animals' brains begins to decline. The hippocampus is associated with both learning and memory. While similar observations have been made previously in the brains of rodents, this is the first time the decrease in new cell growth has been noted in a primate.
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- An AIDS-related virus reveals more ways to cause cancer, Penn researchers find
10-08-2007 · EurekAlert!
Researchers have shed new light on how Kaposi's Sarcoma-associated Herpes Virus subverts normal cell machinery to cause cancer. A KSHV protein called latency-associated nuclear antigen (LANA) helps the virus hide out from the immune system in infected cells. When LANA takes the place of other proteins that control cell growth, it can cause uncontrolled cell replication.
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- There goes the neighborhood: Vascular niche nurtures brain tumor stem cells
01-16-2007 · EurekAlert!
New research published in the January 2007 issue of the journal Cancer Cell, published by Cell Press, reveals that small blood vessels associated with brain tumors orchestrate a distinct microenvironment that is critical for maintaining cancer stem cells (CSCs). Importantly, antiangiogenic drugs that disrupt this microenvironment reduce the CSC population and arrest tumor growth.
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- An AIDS-related virus tricks cells to become tumors, new Penn study finds
11-08-2006 · EurekAlert!
Researchers at the University of Pennsylvania School of Medicine have discovered how the Kaposi's sarcoma-associated herpesvirus (KSHV) subverts a normal cell process in order to promote tumor growth. The finding, published in the most recent issue of PLoS Pathogens, offers new potential strategies for treating Kaposi's sarcoma and other cancers associated with viruses
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- Impaired Gene Helps Nonsmall-cell Lung Cancer Resist Drug
10-02-2006 · ScienceDaily
Lung cancer cells with a defective version of a potential tumor suppressor gene are highly resistant to attack by a platinum-based drug commonly used to treat the disease, researchers at the University of Texas M. D. Anderson Cancer Center and the University of Texas Southwestern Medical Center at Dallas report in the cover article of the Oct. 1 edition of Cancer Research.
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- Signal protein shows promise for blocking tumor promoters in skin cells
11-03-2006 · EurekAlert!
A protein with the ironic name "Srcasm" can counteract the effects of tumor-promoting molecules in skin cells. Using animal models, the researchers discovered that Srcasm acts like a brake in epithelial cells, preventing uncontrolled cell growth caused by a family of proteins called Src kinases. This finding, published online in the Journal of Biological Chemistry, suggests a target for future gene therapy to treat skin, head, neck, colon and breast cancers.
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- Type of stem cell found to reside in transplanted lungs
03-08-2007 · EurekAlert!
A new study involving a type of stem cells from the lungs of transplant patients demonstrates for the first time that these progenitor cells reside in adult organs and are not derived from bone marrow, which leads to the possibility that the cells may be able to help with the rejection of donated organs and with various kinds of lung disease.
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